Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review

We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever. A recurrence of the hypothermia was observed after acetaminophen rechallenge for fever. We reviewed 14 other pediatric cases of hypothermia secondar...

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Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2019-09, Vol.26 (6), p.358-360
Main Authors: Agier, M.-S., Chollet, N., Bediou, E., Boyer Gervoise, M., Jonville-Bera, A.-P.
Format: Article
Language:English
Subjects:
Acetaminophen
Acetaminophen - adverse effects
Antipyretics - adverse effects
Humans
Hypothermia
Hypothermia - chemically induced
Hypothermia - diagnosis
Infant
Life Sciences
Male
Pediatrics
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Summary:We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever. A recurrence of the hypothermia was observed after acetaminophen rechallenge for fever. We reviewed 14 other pediatric cases of hypothermia secondary to therapeutic doses of acetaminophen. Hypothermia after a therapeutic dose is a very rare side effect of acetaminophen. Several hypotheses have been made but the exact mechanism remains unknown.
ISSN:0929-693X
1769-664X
DOI:10.1016/j.arcped.2019.06.005