Harnessing Selectivity and Sensitivity in Ion Sensing via Supramolecular Recognition: A 3D Hybrid Gold Nanoparticle Network Chemiresistor

The monitoring of K+ in saliva, blood, urine, or sweat represents a future powerful alternative diagnostic tool to prevent various diseases. However, several K+ sensors are unable to meet the requirements for the development of point‐of‐care (POC) sensors. To tackle this grand‐challenge, the fabrica...

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Bibliographic Details
Published in:Advanced functional materials 2021-03, Vol.31 (10), p.n/a
Main Authors: Montes‐García, Verónica, Oliveira, Rafael Furlan, Wang, Ye, Berezin, Andrey, Fanjul‐Bolado, Pablo, González García, María Begoña, Hermans, Thomas M., Bonifazi, Davide, Casalini, Stefano, Samorì, Paolo
Format: Article
Language:English
Subjects:
Aqueous environments
Calcium ions
Chemical Sciences
chemiresistors
Gold
Material chemistry
Materials science
metal nanoparticles
Microfluidics
molecular recognition
Nanoparticles
point‐of‐care sensor
Saliva
Selectivity
Sensitivity
Sensors
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Summary:The monitoring of K+ in saliva, blood, urine, or sweat represents a future powerful alternative diagnostic tool to prevent various diseases. However, several K+ sensors are unable to meet the requirements for the development of point‐of‐care (POC) sensors. To tackle this grand‐challenge, the fabrication of chemiresistors (CRs) based on 3D networks of Au nanoparticles covalently bridged by ad‐hoc supramolecular receptors for K+, namely dithiomethylene dibenzo‐18‐crown‐6 ether is reported here. A multi‐technique characterization allows optimizing a new protocol for fabricating high‐performing CRs for real‐time monitoring of K+ in complex aqueous environments. The sensor shows exceptional figures of merit: i) linear sensitivity in the 10–3 to 10–6 m concentration range; ii) high selectivity to K+ in presence of interfering cations (Na+, Ca2+, and Mg2+); iii) high shelf‐life stability (>45 days); iv) reversibility of K+ binding and release; v) successful device integration into microfluidic systems for real‐time monitoring; vi) fast response and recovery times (
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202008554