In vitro and in vivo evaluation of superparamagnetic iron oxide nanoparticles coated by bisphosphonates: The effects of electrical charge and molecule length

Physicochemical coating properties are often considered to be determining factors for in vivo characteristics of superparamagnetic iron oxide nanoparticles, used as contrast agent in Magnetic Resonance Imaging (MRI). To investigate the electrical charge (modified by zero, one or two ammonium groups)...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2013-05, Vol.49 (2), p.101-108
Main Authors: Karimi, A., Denizot, B., Passirani, C., Hindré, F., Roux, J., Legras, P., Le Jeune, J.J.
Format: Article
Language:English
Subjects:
Ammonium Compounds - chemistry
Animals
Biodistribution study
Complement activation
Complement Activation - drug effects
Diphosphonates - administration & dosage
Diphosphonates - chemistry
Electrochemistry
Ferric Compounds - administration & dosage
Ferric Compounds - chemistry
Heart - drug effects
Heart - physiology
Iron oxide nanoparticles
Kidney - drug effects
Kidney - physiology
Life Sciences
Liver - drug effects
Liver - physiology
Lung - drug effects
Lung - physiology
Magnetic Phenomena
Male
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Rats
Rats, Wistar
Relaxation time
Spleen - drug effects
Spleen - physiology
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Summary:Physicochemical coating properties are often considered to be determining factors for in vivo characteristics of superparamagnetic iron oxide nanoparticles, used as contrast agent in Magnetic Resonance Imaging (MRI). To investigate the electrical charge (modified by zero, one or two ammonium groups) and the molecule length (3, 5 or 7 methylene chains) effects of bisphosphonate-type coatings, we assessed the complement activation, in vivo plasma and tissue relaxation time alterations of intravenously injected small iron oxide nanoparticles (
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2013.02.016