Interfacial behavior of lipid nanocapsules spread on model membrane monolayers

The lipid nanocapsules (LNCs) spread at the air–water interface (A/W) undergo destabilization and disaggregation leading to formation of a triglyceride (TG) surface film. The kinetics of reorganization and formation of TG surface film were followed by measuring either the change of surface pressure...

Full description

Saved in:
Bibliographic Details
Published in:Colloid and polymer science 2014-06, Vol.292 (6), p.1307-1318
Main Authors: Ivanova, Tz, Mircheva, K., Balashev, K., Minkov, I., Saulnier, P., Panaiotov, I.
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Colloidal state and disperse state
Complex Fluids and Microfluidics
Exact sciences and technology
Food Science
General and physical chemistry
Life Sciences
Lipids
Membranes
Monolayers
Mucus
Nanostructure
Nanotechnology and Microengineering
Original Contribution
Physical Chemistry
Polymer Sciences
Soft and Granular Matter
Spreads
Surface layer
Surface physical chemistry
Surface pressure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The lipid nanocapsules (LNCs) spread at the air–water interface (A/W) undergo destabilization and disaggregation leading to formation of a triglyceride (TG) surface film. The kinetics of reorganization and formation of TG surface film were followed by measuring either the change of surface pressure at constant area or the surface area at constant surface pressure. From the obtained experimental data were determined the effectiveness of TG spreading and the rate of LNC disaggregation at A/W interface covered with preformed model membrane monolayers of DPPC, Curosurf®, and mucus. Partial LNC stabilization due to their interaction with the model membrane monolayers was observed and characterized by atomic force microscopy (AFM). The obtained results demonstrated that the LNCs spread on mucus surface layer, which models the epithelial surface were more stable than if they were spread either on DPPC or Curosurf® surface layers, which emulate the alveolar surface.
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-014-3180-5