Quantitative approaches of nanofibers organization for biomedical patterned nanofibrous scaffold by image analysis

This study proposes a novel design of a laboratory built static collector using the 3D printing technology. This new collector produces aligned‐to‐random nanofibers in nanofibrous scaffold through electrospinning process. A design of experiment (DOE), based on response surface, analyzes the effect o...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2018-11, Vol.106 (11), p.2963-2972
Main Authors: Shah Hosseini, Neda, Simon, Bertrand, Messaoud, Tahani, Khenoussi, Nabyl, Schacher, Laurence, Adolphe, Dominique
Format: Article
Language:English
Subjects:
collector geometries
design of experiment
Design of experiments
electrospinning
Engineering Sciences
Fourier transforms
Image analysis
Image processing
Mechanics
Nanofibers
nanofibers orientation
Process parameters
Response surface methodology
Scaffolds
Three dimensional printing
Tissue engineering
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Summary:This study proposes a novel design of a laboratory built static collector using the 3D printing technology. This new collector produces aligned‐to‐random nanofibers in nanofibrous scaffold through electrospinning process. A design of experiment (DOE), based on response surface, analyzes the effect of the main process parameters; concentration, voltage, and distance; on the responses diameter and orientation. A quantifying approach has been used to investigate the orientation of nanofibers in the produced patterned scaffold through Fourier transforms method. The obtained results have proven a good potential to be used in tissue engineering application, especially for cells requiring specific guidance. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2963–2972, 2018.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36485