Pigments test strips: A rapid companion test to exclude sub-arachnoid haemorrhage

•Urine test strips (Multistix®) can detect haem pigments in CSF with high sensitivity but low specificity.•Urine test strips negativity fully correlated to absence of clinical SAH.•Urine test strips test is a bedside diagnosis test, easy and fast to perform.•Urine tests strips could help to rule out...

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Bibliographic Details
Published in:Clinica chimica acta 2020-11, Vol.510, p.54-59
Main Authors: Boutin, Julian, Bats, Marie-Lise, Amintas, Samuel, Bérard, Annie, Dabernat, Sandrine, Colombies, Brigitte, Rucheton, Benoit, Bedel, Aurélie
Format: Article
Language:English
Subjects:
Haem pigments detection
Human health and pathology
Life Sciences
Multistix® urine test strips
Spectrophotometry
Subarachnoid haemorrhage
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Summary:•Urine test strips (Multistix®) can detect haem pigments in CSF with high sensitivity but low specificity.•Urine test strips negativity fully correlated to absence of clinical SAH.•Urine test strips test is a bedside diagnosis test, easy and fast to perform.•Urine tests strips could help to rule out the SAH diagnosis when a spectrophotometer is not available. Subarachnoid haemorrhage (SAH) is characterised by 25% of mortality or induces long-term care. It needs immediate diagnosis with computed tomography (CT) scan. For the inconclusive CT scans, the detection of haem pigments can be performed in the cerebrospinal fluid (CSF). The reference method is spectrophotometry but it requires a large volume of CSF, and specific equipment. Sometimes, urine test strips are used as an alternative method for haem pigments detection. However, this method needs validation in SAH context. The aim of the study was to compare the performance of Multistix® urine test strips for haem pigments detection to the reference spectrophotometry and the final clinical SAH diagnosis. We collected 136 CSFs sampled for suspected SAH. We detected haem pigments with urine test strips and spectrophotometry and compared performances for 100 samples. Urine tests strips displayed a high sensitivity (0.97) as compared to the reference spectrophotometry for haem pigments detection. Interestingly, absence of haem pigments fully correlated with absence of SAH. Negative Multistix® urine test strips could help to exclude SAH diagnosis in combination with clinical data when a spectrophotometer is not available, or as a bedside diagnosis test.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2020.06.052