Breath‐holding and tidal breathing nasal NO to screen children for Primary Ciliary Dyskinesia

Nasal nitric oxide (nNO) measurement is recommended to screen for Primary Ciliary Dyskinesia (PCD) in subjects with suggestive history and symptoms. Clinical use of alternative methods (i.e., breath‐hold [BH], tidal breathing [TB]) in children unable to perform the gold standard slow Exhalation agai...

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Bibliographic Details
Published in:Pediatric pulmonology 2021-07, Vol.56 (7), p.2242-2249
Main Authors: Beydon, Nicole, Tamalet, Aline, Escudier, Estelle, Legendre, Marie, Thouvenin, Guillaume
Format: Article
Language:English
Subjects:
Bronchiectasis & Primary Ciliary Dyskinesia
Dyskinesia
Genetics
Human genetics
Life Sciences
nitric oxide (NO)
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Summary:Nasal nitric oxide (nNO) measurement is recommended to screen for Primary Ciliary Dyskinesia (PCD) in subjects with suggestive history and symptoms. Clinical use of alternative methods (i.e., breath‐hold [BH], tidal breathing [TB]) in children unable to perform the gold standard slow Exhalation against a Resistance (ER) method has not been sufficiently evaluated. We extracted retrospectively (2013–2019) 454 files (374 subjects) containing nNO results. Median [IQR] age at inclusion was 7.0 [4.7–11.0] years, 105 (28.1%) children were younger than 5 years. ER or BH methods were more frequently mastered by children older than 5 years compared to younger children (69.4% and 52.7% vs. 21% and 5.6%, respectively; p 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.25432