A Natural Structural Variant of the Mouse TCR beta-Chain Displays Intrinsic Receptor Function and Antigen Specificity

The Cbeta0 alternate cassette exon is located between the Jbeta1 and Cbeta1 genes in the mouse TCR beta-locus. In T cells with a VDJbeta1 rearrangement, the Cbeta0 exon may be included in TCRbeta transcripts (herein called TCRbeta-Cbeta0 transcripts), potentially inserting an additional 24 aa betwee...

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Bibliographic Details
Published in:Journal of Immunology 2006-12, Vol.177 (12), p.8587-8594
Main Authors: Aublin, Anne, Ciofani, Maria, Willkomm, Nancy, Hamrouni, Abdelbasset, Szymczak-Workman, Andrea L, Takahashi, Tomio, Sandjeu, Yongoua, Guillaume, Philippe, Vignali, Dario A. A, Michielin, Olivier, Zuniga-Pflucker, Juan Carlos, Maryanski, Janet L
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cloning, Molecular
Epitopes
Gene Rearrangement
Genes, T-Cell Receptor beta
Hybridomas - cytology
Hybridomas - metabolism
Immunology
Life Sciences
Mice
Protein Isoforms
Receptors, Antigen, T-Cell, alpha-beta - chemistry
Receptors, Antigen, T-Cell, alpha-beta - genetics
Receptors, Antigen, T-Cell, alpha-beta - physiology
T-Lymphocytes - cytology
T-Lymphocytes - metabolism
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Summary:The Cbeta0 alternate cassette exon is located between the Jbeta1 and Cbeta1 genes in the mouse TCR beta-locus. In T cells with a VDJbeta1 rearrangement, the Cbeta0 exon may be included in TCRbeta transcripts (herein called TCRbeta-Cbeta0 transcripts), potentially inserting an additional 24 aa between the V and C domains of the TCR beta-chain. These TCRbeta splice isoforms may be differentially regulated after Ag activation, because we detected TCRbeta-Cbeta0 transcripts in a high proportion (>60%) of immature and mature T cells having VDJbeta1 rearrangements but found a substantially reduced frequency (
ISSN:0022-1767
1550-6606
1365-2567
DOI:10.4049/jimmunol.177.12.8587