Comorbidities Are Associated with Fibrosis in NAFLD Subjects: A Nationwide Study (NASH-CO Study)

Background The relationship between the severity of NAFLD and extra-hepatic events such as cardiovascular disease (CVD), extra-hepatic cancer (EHC) or chronic kidney diseases (CKD) has not been clearly investigated in the general population. Aims The aim of this study was to assess whether the sever...

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Bibliographic Details
Published in:Digestive diseases and sciences 2022-06, Vol.67 (6), p.2584-2593
Main Authors: Nabi, Oumarou, Boursier, Jerome, Lacombe, Karine, Mathurin, Philippe, de Ledinghen, Victor, Goldberg, Marcel, Zins, Marie, Serfaty, Lawrence
Format: Article
Language:English
Subjects:
Adult
Alcohol
Angina pectoris
Biochemistry
Biopsy
Blood pressure
Body mass index
Cardiovascular disease
Cardiovascular Diseases - complications
Cholesterol
Colorectal cancer
Diabetes
Epidemiology
Ethnicity
Fibrosis
Gastroenterology
Glomerular Filtration Rate
Hepatology
Humans
Hypertension
Kidney diseases
Laboratories
Life Sciences
Liver cancer
Liver Cirrhosis - complications
Liver diseases
Medical screening
Medicine
Medicine & Public Health
Metabolism
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - epidemiology
Oncology
Original Article
Population
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Risk Factors
Sociodemographics
Transplant Surgery
Womens health
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Summary:Background The relationship between the severity of NAFLD and extra-hepatic events such as cardiovascular disease (CVD), extra-hepatic cancer (EHC) or chronic kidney diseases (CKD) has not been clearly investigated in the general population. Aims The aim of this study was to assess whether the severity of fibrosis in NAFLD subjects was associated with extra-hepatic diseases based on noninvasive markers in a large population-based cohort. Methods The study population included a cohort of 118,664 participants from the nationwide CONSTANCES cohort. After excluding individuals with excessive alcohol consumption and other causes of liver disease, 102,344 were included. The noninvasive diagnosis of NAFLD and fibrosis was performed using a combination of the Fatty Liver Index (FLI) and the Forns Index. The history of CVD or EHC was recorded by a physician, and CKD was defined by a glomerular filtration rate  60) was 18.2%, 10% with mild fibrosis (Forns Index  6.9). The prevalence of CVD, EHC, or CKD increased significantly with the severity of fibrosis ( p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-021-07032-z