Liver fibrosis staging with contrast-enhanced ultrasonography: prospective multicenter study compared with METAVIR scoring

We prospectively assessed contrast-enhanced sonography for evaluating the degree of liver fibrosis as diagnosed via biopsy in 99 patients. The transit time of microbubbles between the portal and hepatic veins was calculated from the difference between the arrival time of the microbubbles in each vei...

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Bibliographic Details
Published in:European radiology 2009-08, Vol.19 (8), p.1991-1997
Main Authors: Staub, F., Tournoux-Facon, C., Roumy, J., Chaigneau, C., Morichaut-Beauchant, M., Levillain, P., Prevost, C., Aubé, C., Lebigot, J., Oberti, F., Galtier, J. B., Laumonier, H., Trillaud, H., Bernard, P. H., Blanc, J. F., Sironneau, S., Machet, F., Drouillard, J., de Ledinghen, V., Couzigou, P., Foucher, P., Castéra, L., Tranquard, F., Bacq, Y., d’Altéroche, L., Ingrand, P., Tasu, J. P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Algorithms
Biopsy
Contrast Media
Diagnostic Radiology
Female
France
Hepatobiliary-Pancreas
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging
Internal Medicine
Interventional Radiology
Life Sciences
Liver Cirrhosis - classification
Liver Cirrhosis - diagnosis
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Observer Variation
Phospholipids
Radiology
Reproducibility of Results
Sensitivity and Specificity
Sulfur Hexafluoride
Ultrasonography - methods
Ultrasound
Young Adult
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Summary:We prospectively assessed contrast-enhanced sonography for evaluating the degree of liver fibrosis as diagnosed via biopsy in 99 patients. The transit time of microbubbles between the portal and hepatic veins was calculated from the difference between the arrival time of the microbubbles in each vein. Liver biopsy was obtained for each patient within 6 months of the contrast-enhanced sonography. Histological fibrosis was categorized into two classes: (1) no or moderate fibrosis (F0, F1, and F2 according to the METAVIR staging) or (2) severe fibrosis (F3 and F4). At a cutoff of 13 s for the transit time, the diagnosis of severe fibrosis was made with a specificity of 78.57%, a sensitivity of 78.95%, a positive predictive value of 78.33%, a negative predictive value of 83.33%, and a performance accuracy of 78.79%. Therefore, contrast-enhanced ultrasound can help with differentiation between moderate and severe fibrosis.
ISSN:0938-7994
1432-1084
1432-1084
DOI:10.1007/s00330-009-1313-x