A novel spleen‐dedicated stiffness measurement by FibroScan® improves the screening of high‐risk oesophageal varices

Background & Aims Several non‐invasive tests (NITs) have been developed to diagnose oesophageal varices (EV), including the recent Baveno VI criteria to rule out high‐risk varices (HRV). Spleen stiffness measurement (SSM) with the standard FibroScan® (SSM@50Hz) has been evaluated. However, the E...

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Bibliographic Details
Published in:Liver international 2020-01, Vol.40 (1), p.175-185
Main Authors: Stefanescu, Horia, Marasco, Giovanni, Calès, Paul, Fraquelli, Mirella, Rosselli, Matteo, Ganne‐Carriè, Nathalie, Ledinghen, Victor, Ravaioli, Federico, Colecchia, Antonio, Rusu, Corina, Andreone, Pietro, Mazzella, Giuseppe, Festi, Davide
Format: Article
Language:English
Subjects:
Aged
Baveno VI criteria
Criteria
Elasticity Imaging Techniques - methods
Endoscopy
Esophageal and Gastric Varices - diagnosis
Esophageal and Gastric Varices - etiology
Esophagus
Evaluation
Female
Humans
Life Sciences
Liver
Liver diseases
Liver Diseases - complications
liver stiffness measurement
Logistic Models
Male
Middle Aged
Multivariate Analysis
Platelet Count
portal hypertension
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Spleen
Spleen - pathology
Spleen - physiopathology
spleen stiffness measurement
Stiffness
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Description
Summary:Background & Aims Several non‐invasive tests (NITs) have been developed to diagnose oesophageal varices (EV), including the recent Baveno VI criteria to rule out high‐risk varices (HRV). Spleen stiffness measurement (SSM) with the standard FibroScan® (SSM@50Hz) has been evaluated. However, the EV grading could be underestimated because of a ceiling threshold (75 kPa) of the SSM@50Hz. The aims were to evaluate SSM by a novel spleen‐dedicated FibroScan® (SSM@100Hz) for EV diagnosis compared with SSM@50Hz, other validated NITs and Baveno VI criteria. Methods This prospective multicentre study consecutively enrolled patients with chronic liver disease; blood data, endoscopy, liver stiffness measurement (LSM), SSM@50Hz and SSM@100Hz were collected. Results Two hundred and sixty patients met inclusion criteria. SSM@100Hz success rate was significantly higher than that of SSM@50Hz (92.5% vs 76.0%, P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.14228