High Intralesional Interleukin-10 Messenger RNA Expression in Localized Cutaneous Leishmaniasis Is Associated with Unresponsiveness to Treatment

The intralesional expression of cytokines (interleukin [IL]–4, IL-13, IL-10, and interferon-γ) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly highe...

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Bibliographic Details
Published in:The Journal of infectious diseases 2001-12, Vol.184 (12), p.1628-1630
Main Authors: Bourreau, Eliane, Prévot, Ghislaine, Gardon, Jacques, Pradinaud, Roger, Launois, Pascal
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
Biopsies
Child
Complementary DNA
Concise Communication
Cutaneous leishmaniasis
Cytokines
Cytokines - metabolism
Female
Human protozoal diseases
Human viral diseases
Humans
Infectious diseases
interleukin 10
interleukin 13
interleukin 4
Interleukin-10 - genetics
Interleukin-10 - metabolism
Leishmania guyanensis
Leishmania guyanensis - drug effects
Leishmaniasis
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - immunology
Leshmaniasis
Lesions
Life Sciences
Male
Medical sciences
Messenger RNA
Middle Aged
Parasites
Parasitic diseases
Pentamidine - therapeutic use
Protozoal diseases
RNA, Messenger - genetics
RNA, Messenger - metabolism
T lymphocytes
Treatment Failure
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Visceral leishmaniasis
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Summary:The intralesional expression of cytokines (interleukin [IL]–4, IL-13, IL-10, and interferon-γ) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly higher in patients who responded poorly to treatment than in patients whose lesions were regressing. When an IL-10 level >10 (ratio of the concentration of IL-10 [pg/μL] to that of β-actin [pg/μL]) was used as an indicator of treatment failure, the sensitivity of this test was 78.6, and the specificity was 72.5. Thus, high intralesional expression of IL-10 might predict a poor response to conventional treatment
ISSN:0022-1899
1537-6613
DOI:10.1086/324665