Sodium alginate and alginic acid as pharmaceutical excipients for tablet formulation: Structure-function relationship

Alginic acid and its sodium salt are well-accepted pharmaceutical excipients fulfilling several roles in the development of solid oral dosage forms. Although they have attractive advantages as safety, abundance, relatively low cost and biodegradability, these natural polysaccharides possess a high v...

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Bibliographic Details
Published in:Carbohydrate polymers 2021-10, Vol.270, p.118399-118399, Article 118399
Main Authors: Sanchez-Ballester, Noelia M., Bataille, Bernard, Soulairol, Ian
Format: Article
Language:English
Subjects:
Alginates - chemistry
Alginic acid
Alginic Acid - chemistry
Biosourced
Chemical Sciences
Direct compression
Drug Compounding - methods
Drug Liberation
Excipients - chemistry
Humans
Magnetic Resonance Spectroscopy - methods
Molecular Weight
Particle Size
Pharmaceutical excipient
Sodium alginate
Solubility
Structure-Activity Relationship
Tablet formulations
Tablets - chemistry
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Summary:Alginic acid and its sodium salt are well-accepted pharmaceutical excipients fulfilling several roles in the development of solid oral dosage forms. Although they have attractive advantages as safety, abundance, relatively low cost and biodegradability, these natural polysaccharides possess a high variability that may limit their use as excipients for tablet formulation. Thus, to obtain robust formulations and high-quality drug products with consistent performance a complete understanding of the structure-property relationship becomes necessary as the structure of alginates affects both, technological and biopharmaceutical properties. This review compiles the compaction studies carried out that relate the structure of alginates to their mechanical and dissolution performances. The different analytical methods used to determine the chemical composition, primary structure and molecular weight distribution, major factors affecting the behavior of alginates in direct compression, are also exposed. Finally, different strategies reported to improve the properties of alginic acid as direct compression excipient are discussed. •Structure-functionality relation of alginic acid and sodium alginate as direct compression excipients•Alginates structure and composition affects its functionality and behavior in the compression process.•Due to their high variability, physicochemical characterization of alginates is essential to exploit them as excipients.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2021.118399