Characteristics and treatment outcome of suicidal depression: Two large naturalistic cohorts of depressed outpatients

Objective: The emergence of new drugs for managing suicidal ideation (e.g. ketamine) raises the question of whether suicidal depression (i.e. moderate to severe depression with concomitant suicidal ideation) is a specific depression phenotype. Therefore, this study characterized patients with suicid...

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Published in:Australian and New Zealand journal of psychiatry 2022-04, Vol.56 (4), p.347-364
Main Authors: Nobile, Bénédicte, Olié, Emilie, Dubois, Jonathan, Guillaume, Sebastien, Gorwood, Philip, Courtet, Philippe
Format: Article
Language:English
Subjects:
Human health and pathology
Humans
Life Sciences
Neurons and Cognition
Outpatients
Prospective Studies
Psychiatric Status Rating Scales
Suicidal Ideation
Treatment Outcome
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Summary:Objective: The emergence of new drugs for managing suicidal ideation (e.g. ketamine) raises the question of whether suicidal depression (i.e. moderate to severe depression with concomitant suicidal ideation) is a specific depression phenotype. Therefore, this study characterized patients with suicidal depression (baseline clinical characteristics, suicidal ideation and depression evolutions, suicide risk) in two large cohorts of outpatients with depression. Methods: LUEUR and GENESE are two large, prospective, naturalistic cohorts of French adult outpatients with depression (Diagnostic and Statistical Manual of Mental Disorders, fourth edition, criteria), treated and followed up for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale, and suicidal ideation with the suicidal item of the Montgomery–Åsberg Depression Rating Scale. Patients with moderate or severe depression (Hospital Anxiety and Depression Scale–Depression subscale score >11) were selected and classified as without suicidal ideation (suicidal item of the Montgomery–Åsberg Depression Rating Scale
ISSN:0004-8674
1440-1614
DOI:10.1177/00048674211025697