Cardiovascular changes during the sleep-wake cycle in spontaneous hypertensive rats and in their genetically normotensive precursors

Blood pressure and heart rate were recorded in spontaneously hypertensive rats (SH) and in their genetically normotensive precursors (WKY) during the sleep-wake cycle using a computer-assisted method. Similar results were obtained in both strains: (a) No significant difference was observed in blood...

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Bibliographic Details
Published in:Pflügers Archiv 1988-02, Vol.411 (2), p.195-199
Main Authors: MEUNIER, J. M, NOSJEAN, A, LACOMBE, J, LAGUZZI, R
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Cognitive Sciences
Experimental diseases
Heart Rate
Life Sciences
Male
Medical sciences
Neurobiology
Neurons and Cognition
Psychology and behavior
Rats
Rats, Inbred SHR
Rats, Inbred SHR - physiology
Rats, Inbred Strains
Rats, Inbred Strains - physiology
Rats, Inbred WKY
Rats, Inbred WKY - physiology
Sleep
Sleep - physiology
Species Specificity
Wakefulness
Wakefulness - physiology
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Summary:Blood pressure and heart rate were recorded in spontaneously hypertensive rats (SH) and in their genetically normotensive precursors (WKY) during the sleep-wake cycle using a computer-assisted method. Similar results were obtained in both strains: (a) No significant difference was observed in blood pressure values between slow-wave-sleep (SWS) and the last 2 min of the preceding wakefulness (W) episode within the complete cycle; blood pressure then increased during PS. (b) Heart rate values during SWS were significantly lower than those computed for W; a further fall of heart rate was observed during paradoxical sleep (PS) only in hypertensive rats. (c) During SWS the blood pressure and heart rate variability was significantly lower than during W and PS. In addition, blood pressure variability values during the three sleep-wake states were lower in hypertensive than in normotensive rats. These data suggest that there are no qualitative differences in the mechanisms that control circulation during sleep in normotensive and spontaneous hypertensive rats.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00582314