Impact of epicatechin on fibrin clot structure

Fibrin clot structure and function are major determinants of thromboembolic diseases. The study aim was to determine the impact of epicatechin (a flavonoid with cardiovascular protective effects) on fibrin clot structure and permeability. Plasma samples from 12 healthy subjects were incubated with i...

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Bibliographic Details
Published in:European journal of pharmacology 2021-02, Vol.893, p.173830-173830, Article 173830
Main Authors: Sinegre, Thomas, Milenkovic, Dragan, Teissandier, Dorian, Fully, Pauline, Bourdin, Julien, Morand, Christine, Lebreton, Aurélien
Format: Article
Language:English
Subjects:
Adult
Blood Coagulation - drug effects
Cardiovascular disease
Catechin - pharmacology
Coagulation
Epicatechin
Female
Fibrin - metabolism
Fibrin - ultrastructure
Fibrin clot
Fibrinolytic Agents - pharmacology
Healthy Volunteers
Humans
Kinetics
Life Sciences
Male
Middle Aged
Permeability
Pharmaceutical sciences
Pharmacology
Turbidity
Young Adult
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Summary:Fibrin clot structure and function are major determinants of thromboembolic diseases. The study aim was to determine the impact of epicatechin (a flavonoid with cardiovascular protective effects) on fibrin clot structure and permeability. Plasma samples from 12 healthy subjects were incubated with increasing concentrations of epicatechin. Turbidity of fibrin clot was analyzed by absorbance measurement at 405 nm. The fibrin clot nanostructure was determined by scanning spectrometry (wavelength from 500 to 800 nm) and fibrin fiber size by electron microscopy. Permeability was analyzed to assess the fibrin clot functional properties. Epicatechin addition increased the maximum absorbance from 0.34 ± 0.066 (vehicle) to 0.35 ± 0.077 (P = 0.1), 0.35 ± 0.072 (P 
ISSN:0014-2999
1879-0712
1879-0712
0014-2999
DOI:10.1016/j.ejphar.2020.173830