Cobalt, chromium and nickel affect hydroxyapatite crystal growth in vitro

Metals are widely used in orthopaedics and recent studies have reported that patients with metal implants have a significant increase of metal levels in serum and synovial fluid. Femoral neck fracture occurred in some patients with metal-on-metal implants for unknown reasons. Recently, bone quality...

Full description

Saved in:
Bibliographic Details
Published in:Acta biomaterialia 2010-04, Vol.6 (4), p.1555-1560
Main Authors: Mabilleau, G., Filmon, R., Petrov, P.K., Baslé, M.F., Sabokbar, A., Chappard, D.
Format: Article
Language:English
Subjects:
Calcium - chemistry
Chromium - pharmacology
Cobalt - pharmacology
Crystal size
Crystallinity
Crystallization
Durapatite - chemistry
Hydroxyapatite
Life Sciences
Metal
Microscopy, Electron, Scanning
Mineralization
Nickel - pharmacology
Phosphates - chemistry
Polyhydroxyethyl Methacrylate - chemistry
Surface Properties - drug effects
X-Ray Diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metals are widely used in orthopaedics and recent studies have reported that patients with metal implants have a significant increase of metal levels in serum and synovial fluid. Femoral neck fracture occurred in some patients with metal-on-metal implants for unknown reasons. Recently, bone quality has emerged as an important factor of bone strength and few studies have investigated the effects of metal ions on hydroxyapatite properties. In the present study, we investigated the effects of Co 2+, Cr 3+ and Ni 2+ on hydroxyapatite (HA) growth in vitro, using carboxymethylated poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial for calcification. We have demonstrated that metal ions reduced the quantity of mineral formed at the surface of the polymer and decreased the ratio Ca/P by 1.12-, 1.05- and 1.08-fold for Cr 2+, Cr 3+ and Ni 2+ respectively. Furthermore, the size of calcospherites was significantly increased in the metal-doped HA compared to the controls, indicating a possible effect of metal ions on the crystal lattice. Indeed, the presence of metal ions increased the crystal size as well as the crystallinity of HA and reduce the lattice parameter c of the HA framework. The information obtained from this work suggests that the quality of the mineral around metallic implants could be altered. However, further investigation should be conducted to further elucidate the effects of metal incorporation on bone mineral and the functional consequences.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2009.10.035