Intraepidermal nerve fibres are not the exclusive tranducers of nociception

•Intraepidermal nerve fibres are not the exclusive tranducers of nociception.•Keratinocytes can directly initiate nociceptive responses.•Intraepidermal nerve fibres and keratinocytes may act as a two-receptor-site model. The goal of this article is to provide an insight of the most recent data on cu...

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Bibliographic Details
Published in:Journal of neuroscience methods 2018-08, Vol.306, p.92-93
Main Authors: Talagas, Matthieu, Lebonvallet, Nicolas, Misery, Laurent
Format: Article
Language:English
Subjects:
Electrodes
Free nerve endings
Keratinocytes
Life Sciences
Pain
Stimulation
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Summary:•Intraepidermal nerve fibres are not the exclusive tranducers of nociception.•Keratinocytes can directly initiate nociceptive responses.•Intraepidermal nerve fibres and keratinocytes may act as a two-receptor-site model. The goal of this article is to provide an insight of the most recent data on cutaneous nociception. Indeed recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intraepidermal free nerve endings are not exclusive transducers of pain. Therefore, the results of neurophysiological studies should be interpreted in the light of this information.
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2018.05.013