Predicting daytime sleepiness and fatigue: a 9-year prospective study in myotonic dystrophy type 1

Objective Daytime sleepiness and fatigue are prominent symptoms of myotonic dystrophy type I (DM1) that exact a heavy toll on patients’ quality of life, but information is scarce on their predictive factors. This study aimed to determine factors that may influence levels of daytime sleepiness and fa...

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Bibliographic Details
Published in:Journal of neurology 2020-02, Vol.267 (2), p.461-468
Main Authors: Laberge, Luc, Gallais, Benjamin, Auclair, Julie, Dauvilliers, Yves, Mathieu, Jean, Gagnon, Cynthia
Format: Article
Language:English
Subjects:
Adult
Daytime
Disease Progression
Disorders of Excessive Somnolence
Dystrophy
Fatigue
Female
Follow-Up Studies
Health risk assessment
Humans
Hypothyroidism
Life Sciences
Male
Medicine
Medicine & Public Health
Mental depression
Middle Aged
Myotonic Dystrophy
Neurology
Neurons and Cognition
Neuroradiology
Neurosciences
Original Communication
Prospective Studies
Psychological Distress
Quality of life
Regression analysis
Risk Factors
Sleep
Sleep and wakefulness
Sleep deprivation
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Summary:Objective Daytime sleepiness and fatigue are prominent symptoms of myotonic dystrophy type I (DM1) that exact a heavy toll on patients’ quality of life, but information is scarce on their predictive factors. This study aimed to determine factors that may influence levels of daytime sleepiness and fatigue in a large cohort of DM1 patients followed for 9 years. Methods This study included 115 patients with DM1 at baseline (Time 1, T 1) and at Time 2 ( T 2) who were questioned for daytime sleepiness, fatigue, history of depression, psychological distress, pain, hypothyroidism, and sleep habits. Also, their muscular impairment and intellectual quotient were evaluated. Regression models were used to identify correlates of daytime sleepiness and fatigue while controlling for time effect. Results Both daytime sleepiness and fatigue increased between T 1 and T 2, but their rate of change are higher when CTG repeat number is higher ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-019-09592-7