Building consensus in neuromesodermal research: Current advances and future biomedical perspectives

The development of the vertebrate body axis relies on the activity of different populations of axial progenitors, including neuromesodermal progenitors. Currently, the term ‘Neuromesodermal progenitors’ is associated with various definitions. Here, we use distinct terminologies to highlight advances...

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Bibliographic Details
Published in:Current opinion in cell biology 2021-12, Vol.73, p.133-140
Main Authors: Binagui-Casas, Anahí, Dias, André, Guillot, Charlène, Metzis, Vicki, Saunders, Dillan
Format: Article
Language:English
Subjects:
Body Patterning
Consensus
Development Biology
Life Sciences
Mesoderm
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Summary:The development of the vertebrate body axis relies on the activity of different populations of axial progenitors, including neuromesodermal progenitors. Currently, the term ‘Neuromesodermal progenitors’ is associated with various definitions. Here, we use distinct terminologies to highlight advances in our understanding of this cell type at both the single-cell and population levels. We discuss how these recent insights prompt new opportunities to address a range of biomedical questions spanning cancer metastasis, congenital disorders, cellular metabolism, regenerative medicine, and evolution. Finally, we outline some of the major unanswered questions and propose future directions at the forefront of neuromesodermal research.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2021.08.003