Arterial Stiffness and Stroke in Sickle Cell Disease

Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke. Carotid arterial stiffness, intima-media thickness, and trans...

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Bibliographic Details
Published in:Stroke (1970) 2012-04, Vol.43 (4), p.1129-1130
Main Authors: BELIZNA, Cristina, LOUFRANI, Laurent, GHALI, Alaa, LAHARY, Agnes, PRIMARD, Etienne, LOUVEL, Jean-Pierre, HENRION, Daniel, LEVESQUE, Hervé, IFRAH, Norbert
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - diagnostic imaging
Anemia, Sickle Cell - physiopathology
Biological and medical sciences
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Life Sciences
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Stroke - diagnostic imaging
Stroke - etiology
Stroke - physiopathology
Ultrasonography, Doppler, Transcranial
Vascular diseases and vascular malformations of the nervous system
Vascular Stiffness
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Summary:Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke. Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured. Arterial stiffness and transcranial Doppler velocity were significantly increased in 49 patients with sickle cell disease compared with 47 control subjects (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.111.635383