Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes

A new type of di-functionalized ferrocene is used directly as reactive synthons for DNA/RNA synthesizer to elaborate electronic DNA probes. The use of 1-[3- O-(2-cyanoethyl- N, N-diisopropylphosphor amidityl)propyl]ferrocene and 1-[3- O-dimethoxytrityl propyl]-1′-[3′- O-(2-cyanoethyl- N, N-diisoprop...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (10), p.2439-2441
Main Authors: Navarro, Aude-Emmanuelle, Spinelli, Nicolas, Chaix, Carole, Moustrou, Corinne, Mandrand, Bernard, Brisset, Hugues
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical chemistry
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemical Sciences
Chemistry
DNA
DNA Probes - chemical synthesis
Dna, deoxyribonucleoproteins
Electrochemical methods
Electrochemistry
Exact sciences and technology
Ferrocene
Ferrous Compounds - chemistry
Fundamental and applied biological sciences. Psychology
Metallocenes
Nucleic Acid Hybridization
Nucleic acids
Oligonucleotides
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Organophosphorus Compounds
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Summary:A new type of di-functionalized ferrocene is used directly as reactive synthons for DNA/RNA synthesizer to elaborate electronic DNA probes. The use of 1-[3- O-(2-cyanoethyl- N, N-diisopropylphosphor amidityl)propyl]ferrocene and 1-[3- O-dimethoxytrityl propyl]-1′-[3′- O-(2-cyanoethyl- N, N-diisopropylphosphoramidityl) propyl] ferrocene as reactive synthons for DNA/RNA synthesizer allows to generate ferrocene-labelled oligonucleotides with remarkable DNA detection properties.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.03.016