The emerging role of miRNA-132/212 cluster in neurologic and cardiovascular diseases: Neuroprotective role in cells with prolonged longevity

• Published in: Mechanisms of ageing and development 2021-10, Vol.199, p.111566-111566, Article 111566
• Main Authors: El Fatimy, Rachid, Boulaassafre, Soukayna, Bouchmaa, Najat, El Khayari, Abdellatif, Vergely, Catherine, Malka, Gabriel, Rochette, Luc
• Format: Article
• Language: English
• Subjects: Animals; Cardiology and cardiovascular system; Cardiovascular; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - pathology; Cardiovascular Diseases - therapy; Cellular Senescence; Gene Expression Regulation; Human health and pathology; Humans; Life Sciences; MicroRNAs - metabolism; miRNA-132/212; Molecular Targeted Therapy - methods; Molecular Targeted Therapy - trends; Molecular therapy; Myocytes, Cardiac - physiology; Neurodegeneration; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - therapy; Neurology; Neurons - physiology; Neuroprotection - physiology; Neuroprotective
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/j.mad.2021.111566

•The miRNAs 132/212 have a crucial role in the functioning and physiopathology of both neurological and cardiological systems, demonstrating their regulatory capabilities.•miRNAs as critical biomarkers for the diagnosis of precise heart and brain diseases especially for neurodegenerative and psychiatric disorders.•The dysregulation expression of miRNA-132/212 could be an excellent diagnosis method and an innovative beneficial functional therapeutic with its protective function for cells with prolonged longevity including neurons and cardiomyocytes.•The miRNA-132/212 manipulation can be used in the potential regeneration of cardiomyocytes and neurons both known as near to the ground cell renew and thus as a new treatment to block the progression of described diseases.•Specific modulation of miRNA-132/212 can block the progression of all described diseases. miRNA-132/212 are small regulators of gene expression with a function that fulfills a vital function in diverse biological processes including neuroprotection of cells with prolonged longevity in neurons and the cardiovascular system. In neurons, miRNA-132 appears to be essential for controlling differentiation, development, and neural functioning. Indeed, it also universally promotes axon evolution, nervous migration, plasticity as well, it is suggested to be neuroprotective against neurodegenerative diseases. Moreover, miRNA-132/212 disorder leads to neural developmental perturbation, and the development of degenerative disorders covering Alzheimer’s, Parkinson’s, and epilepsy’s along with psychiatric perturbations including schizophrenia. Furthermore, the cellular mechanisms of the miRNA-132/212 have additionally been explored in cardiovascular diseases models. Also, the miRNA-132/212 family modulates cardiac hypertrophy and autophagy in cardiomyocytes. The protective and effective clinical promise of miRNA-132/212 in these systems is discussed in this review. To sum up, the current progress in innovative miRNA-based therapies for human pathologies seems of extreme concern and reveals promising novel therapeutic strategies.