B cells differentiate in human thymus and express AIRE

• Published in: Journal of allergy and clinical immunology 2017-03, Vol.139 (3), p.1049-1052.e12
• Main Authors: Gies, Vincent, Guffroy, Aurélien, MD, Danion, François, MD, Billaud, Philippe, MD, Keime, Céline, PhD, Fauny, Jean-Daniel, PhD, Susini, Sandrine, PhD, Soley, Anne, LT, Martin, Thierry, MD, PhD, Pasquali, Jean-Louis, MD, PhD, Gros, Frédéric, PhD, André-Schmutz, Isabelle, PhD, Soulas-Sprauel, Pauline, PharmD, PhD, Korganow, Anne-Sophie, MD, PhD
• Format: Article
• Language: English
• Subjects: AIRE Protein; Allergy and Immunology; Antigens; B-Lymphocytes - cytology; B-Lymphocytes - metabolism; Cell Differentiation - physiology; Cellular Biology; Cytochrome; Female; Homeostasis; Humans; Immunoglobulins; Infant; Infant, Newborn; Kinases; Life Sciences; Lymphocyte receptors; Male; Phosphatase; Proteins; Rodents; T cell receptors; Thymus Gland - cytology; Transcription Factors - biosynthesis
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2016.09.044

If relevant, AIRE expression in thymic B cells may repress or induce the expression of other genes, as the induction of TRAs expression in medullary thymic epithelial cells (mTECs).8 Little is known about the nature of TRAs expressed by murine thymic B cells, and there is only a very limited overlap of TRAs between mTECs and extrathymic Aire-expressing cells,3 suggesting that thymic B cells may regulate the expression of a unique set of TRAs.\n50 4.62 x 10-21 ZMIZ1 Zinc finger, MIZ-type containing 1 5.49 9.73 x 10-54 PER1 Period circadian clock 1 5.43 2.24 x 10-10 LRP8 Low-density lipoprotein receptor-related protein 8, apolipoprotein e receptor 5.41 6.15 x 10-15 FOLR2 Folate receptor 2 (fetal) 5.38 9.01 x 10-08 TIE1 Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 5.35 5.38 x 10-07 WDR62 WD repeat domain 62 5.33 2.73 x 10-09 SMIM24 Small integral membrane protein 24 5.29 2.67 x 10-05 ROR1 Receptor tyrosine kinase-like orphan receptor 1 5.11 1.08 x 10-20 INPP1 Inositol polyphosphate-1-phosphatase 5.06 3.31 x 10-18 GBP2 Guanylate binding protein 2, interferon-inducible 5.03 9.60 x 10-26 HLX H2.0-like homeobox 4.99 1.35 x 10-16 CYB5R2 Cytochrome b5 reductase 2 4.93 4.08 x 10-09 TMEM132A Transmembrane protein 132A 4.92 1.79 x 10-21 LPIN1 Lipin 1 4.80 1.00 x 10-27 CSRNP1 Cysteine-serine-rich nuclear protein 1 4.75 4.98 x 10-24 PLXNB1 Plexin B1 4.74 5.54 x 10-05 BAMBI BMP and activin membrane-bound inhibitor 4.74 3.73 x 10-08 MS4A4A Membrane-spanning 4-domains, subfamily A, member 4A 4.72 2.31 x 10-04 MMP14 Matrix metallopeptidase 14 (membrane-inserted) 4.69 6.63 x 10-04 ANK2 Ankyrin 2, neuronal 4.62 7.80 x 10-04 HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 4.59 2.30 x 10-27 RTN2 Reticulon 2 4.59 6.66 x 10-05 CYP2J2 Cytochrome P450, family 2, subfamily J, polypeptide 2 4.59 2.71 x 10-09 EPS8L1 EPS8-like 1 4.57 6.50 x 10-04 SCN1B Sodium channel, voltage gated, type I beta subunit 4.53 6.70 x 10-06 ZYX Zyxin 4.53 1.03 x 10-24 TUBA1C Tubulin, alpha 1c 4.52 1.14 x 10-06 SPHK1 Sphingosine kinase 1 4.49 4.47 x 10-05 STIL SCL/TAL1 interrupting locus 4.46 3.05 x 10-03 TLN2 Talin 2 4.43 5.89 x 10-05 CIT Citron rho-interacting serine/threonine kinase 4.41 5.57 x 10-03 AKAP12[low *]E12,E13 A kinase (PRKA) anchor protein 12 4.40 7.01 x 10-08 NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 4.38 5.71 x 10-10 PDE9A Phosphodiesterase 9A 4.36 6.26 x 10-07 NET1 Neuroepithelial cell transforming 1 4.32 2.17 x 10-14 CISH Cytokine inducib