The Phosphatase PRL-3 Is Involved in Key Steps of Cancer Metastasis

PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but many studies have identified that PRL-3 is a marker of cancer progression and shown it to be associated with metastasis. Evidence implicating PRL-3 in various elements of the metastatic process, such as the cell...

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Bibliographic Details
Published in:Journal of molecular biology 2019-08, Vol.431 (17), p.3056-3067
Main Authors: Duciel, Laura, Monraz Gomez, Luis Cristobal, Kondratova, Maria, Kuperstein, Inna, Saule, Simon
Format: Article
Language:English
Subjects:
Life Sciences
metastasis
phosphatase
signaling pathways
systems biology
tumorigenesis
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Summary:PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but many studies have identified that PRL-3 is a marker of cancer progression and shown it to be associated with metastasis. Evidence implicating PRL-3 in various elements of the metastatic process, such as the cell cycle, survival, angiogenesis, adhesion, cytoskeleton remodeling, EMT, motility and invasion, has been reported. Furthermore, several molecules acting as direct or indirect substrates have been identified. However, this information was obtained in many different studies, and it remains difficult to see the larger picture. We therefore systematically collected the published information together and used it to develop a comprehensive signaling network map. By analyzing this network map, we were able to retrieve the signaling pathways via which PRL-3 governs the key steps of the metastatic process in cancer. In this review, we summarize current knowledge of the role of PRL-3 in cancer and the molecular mechanisms involved. We also provide the web-based open-source PRL-3 signaling network map, for use in further studies. [Display omitted] •The phosphatase PRL-3 regulates numerous pathways driving tumorigenesis and metastasis.
ISSN:0022-2836
1089-8638
DOI:10.1016/j.jmb.2019.06.008