DNA Content, Cell Size, and Cell Senescence

A recent study assessed the impact of cell size on various cell properties. Oversized yeast cells display slow cell division, cytoplasmic dilution, and transcriptomic and proteomic alterations. It highlights commonalities between aging yeast and mammalian cells, suggesting the existence of a range o...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2019-08, Vol.44 (8), p.645-647
Main Author: Veitia, Reiner A.
Format: Article
Language:English
Subjects:
Aging
Animals
Cell Size
Cellular Senescence
Cytoplasm
DNA
Life Sciences
Proteomics
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Summary:A recent study assessed the impact of cell size on various cell properties. Oversized yeast cells display slow cell division, cytoplasmic dilution, and transcriptomic and proteomic alterations. It highlights commonalities between aging yeast and mammalian cells, suggesting the existence of a range of DNA content: cell volume ratio ensuring optimal function.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2019.04.013