Lipoic acid a multi-level molecular inhibitor of tumorigenesis

We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer trea...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Reviews on cancer 2020-01, Vol.1873 (1), p.188317-188317, Article 188317
Main Authors: Farhat, D., Lincet, H.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
Cancer
Carcinogenesis - drug effects
Carcinogenesis - genetics
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Proliferation - genetics
Chemoresistance
Epithelial-Mesenchymal Transition - drug effects
Epithelial-Mesenchymal Transition - genetics
Gene Expression Regulation, Neoplastic - drug effects
Humans
Life Sciences
Lipoic acid
Metastasis
Proliferation
Thioctic Acid - pharmacology
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Summary:We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer treatment.
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2019.188317