Prostate cancer local staging using biparametric MRI: assessment and comparison with multiparametric MRI

• Published in: European journal of radiology 2020-11, Vol.132, p.109350-109350, Article 109350
• Main Authors: Christophe, Charlotte, Montagne, Sarah, Bourrelier, Stéphanie, Roupret, Morgan, Barret, Eric, Rozet, François, Comperat, Eva, Coté, Jean François, Lucidarme, Olivier, Cussenot, Olivier, Granger, Benjamin, Renard-Penna, Raphaële
• Format: Article
• Language: English
• Subjects: Aged; Humans; Life Sciences; Magnetic resonance imaging; Male; Middle Aged; Multiparametric Magnetic Resonance Imaging; Neoplasm staging; Neoplasm Staging - methods; Perfusion imaging; Prostate neoplasms; Prostatectomy; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - surgery; Retrospective Studies
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2020.109350

•The use of a bp-MRI protocol did not result in a decrease of local staging accuracy.•Maximal diameter of the lesion and T2 weighted imaging features are significantly associated with EPE (curvilinear capsular contact >10 mm, irregularity and bulging) The value of adding dynamic contrast-enhanced (DCE) imaging to T2-weighted (T2W) magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) to improve the detection and staging of prostate cancer (PCa) is unclear. The aim of this retrospective study was to compare the diagnostic performance of non-contrast biparametric MRI (bpMRI) with multiparametric MRI (mpMRI), for local staging of PCa. Ninety-two patients who underwent prostate MRI on a 3-Tesla MRI system before radical prostatectomy for PCa were included retrospectively. Four readers independently assigned a Likert score (ranging from 1 to 5) for predicting extra-prostatic extension (EPE) on T2W + DWI (bpMRI) and then on T2W + DWI + DCE imaging (mpMRI). MRI-based staging results were compared with radical prostatectomy histology. A prediction of EPE generalized linear mixed model was used to assess the added-value of DCE and discriminative power of staging accuracy by area under the receiver-operating curve (AUC ROC). AUC was not significantly improved by DCE (mpMRI, AUC = 0.73 [95%CI: 0.655‒0.827] vs. bpMRI, AUC = 0.76 [95%CI: 0.681‒0.846]). After applying a selection procedure, only MRI criteria were retained in a multivariate model. The following criteria were significantly associated with local extension: localization in the peripheral zone (p