Protein S100B as a reliable tool for early prognostication after cardiac arrest

Early and reliable prognostication after cardiac arrest (CA) remains crucial. We hypothesized that protein-S100B (PS100B) could predict more accurately outcome in the early phase of CA compared with other current biomarkers. This prospective single-center study included 330 adult comatose non-trauma...

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Bibliographic Details
Published in:Resuscitation 2020-11, Vol.156, p.251-259
Main Authors: Deye, Nicolas, Nguyen, Philippe, Vodovar, Nicolas, Sadoune, Malha, Collet, Corinne, Voicu, Sebastian, Malissin, Isabelle, Gayat, Etienne, Samuel, Jeanne-Lise, Delcayre, Claude, Launay, Jean-Marie, Cohen-Solal, Alain, Mégarbane, Bruno, Mebazaa, Alexandre
Format: Article
Language:English
Subjects:
Adult
Biomarker
Biomarkers
Heart arrest
Heart Arrest - therapy
Humans
Hypothermia, Induced
Life Sciences
NSE
Outcome
Phosphopyruvate Hydratase
Prognosis
Prognostication
Prospective Studies
Protein S100B
ROC Curve
S100 Calcium Binding Protein beta Subunit
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Summary:Early and reliable prognostication after cardiac arrest (CA) remains crucial. We hypothesized that protein-S100B (PS100B) could predict more accurately outcome in the early phase of CA compared with other current biomarkers. This prospective single-center study included 330 adult comatose non-traumatic successfully resuscitated CA patients, treated with targeted temperature management but not extra-corporeal life support. Lactate, pH, creatinine, NSE, and PS100B were sampled in ICU early after return of spontaneous circulation (ROSC) corresponding to admission (Adm). Serial measurements were also performed at H24 and H48. PS100B was the sole biomarker blinded to physicians. The median delay between ROSC and first PS100B sampling was 220 min. At admission, all biomarkers were significantly associated with good outcome (CPC1–2; 109 patients) at 3-month follow-up (P ≤ 0.001, except for NSE: P = 0.03). PS100B-Adm showed the best AUC of ROC curves for outcome prediction at 3-month (AUC 0.83 [95%-CI: 0.78−0.88]), compared with other biomarkers (P 
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2020.08.010