Effect of micro- and nanoparticle shape on biological processes

In the drug delivery field, there is beyond doubt that the shape of micro- and nanoparticles (M&NPs) critically affects their biological fate. Herein, following an introduction describing recent technological advances for designing nonspherical M&NPs, we highlight the role of particle shape...

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Bibliographic Details
Published in:Journal of controlled release 2022-02, Vol.342, p.93-110
Main Authors: Hadji, Hicheme, Bouchemal, Kawthar
Format: Article
Language:English
Subjects:
Biodistribution
Cell internalization
Cytotoxicity
Life Sciences
Nanoparticle
Pharmaceutical sciences
Pharmacokinetics
Shape
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Summary:In the drug delivery field, there is beyond doubt that the shape of micro- and nanoparticles (M&NPs) critically affects their biological fate. Herein, following an introduction describing recent technological advances for designing nonspherical M&NPs, we highlight the role of particle shape in cell capture, subcellular distribution, intracellular drug delivery, and cytotoxicity. Then, we discuss theoretical approaches for understanding the effect of particle shape on internalization by the cell membrane. Subsequently, recent advances on shape-dependent behaviors of M&NPs in the systemic circulation are detailed. In particular, the interaction of M&NPs with blood proteins, biodistribution, and circulation under flow conditions are analyzed. Finally, the hurdles and future directions for developing nonspherical M&NPs are underscored. [Display omitted] •Cell uptake and intracellular distribution are mediated by particle shape•Nonspherical particles had a better escaping capability to macrophages•Nonspherical particles had a higher margination and adhesion to the endothelial wall•They displayed a longer circulation time and a slower elimination rate•They showed in several endeavours a higher accumulation in the tumoral tissue
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2021.12.032