DNA Repair Gene ERCC2, XPC, XRCC1, XRCC3 Polymorphisms and Associations with Bladder Cancer Risk in a French Cohort

In polygenic diseases, association studies look for genetic variation such as polymorphisms in low penetrance genes, i.e. genes in interaction with environmental factors. DNA repair systems that protect the genome from deleterious endogenous and exogenous damage have been shown to significantly redu...

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Bibliographic Details
Published in:Anticancer research 2008-05, Vol.28 (3B), p.1853-1856
Main Authors: FONTANA, Luc, BOSVIEL, Rémy, BIGNON, Yves-Jean, BERNARD-GALLON, Dominique J, DELORT, Laetitia, GUY, Laurent, CHALABI, Nasséra, KWIATKOWSKI, Fabrice, SATIH, Samir, RABIAU, Nadège, BOITEUX, Jean-Paul, CHAMOUX, Alain
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cancer
Case-Control Studies
Cohort Studies
DNA Repair - genetics
DNA-Binding Proteins - genetics
France
Gene Frequency
Genetic Predisposition to Disease
Humans
Life Sciences
Male
Medical sciences
Nephrology. Urinary tract diseases
Polymorphism, Single Nucleotide
Smoking
Tumors
Tumors of the urinary system
Urinary Bladder Neoplasms - genetics
Urinary tract. Prostate gland
X-ray Repair Cross Complementing Protein 1
Xeroderma Pigmentosum Group D Protein - genetics
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Summary:In polygenic diseases, association studies look for genetic variation such as polymorphisms in low penetrance genes, i.e. genes in interaction with environmental factors. DNA repair systems that protect the genome from deleterious endogenous and exogenous damage have been shown to significantly reduce activity. In particular, enzymes of the nucleotide excision repair pathway are suspected to be implicated in cancer. In this study bladder cancer which is viewed as a polygenic disease was investigated. The functional polymorphisms of four DNA repair genes, excision repair cross-complementing group 2 (ERCC2), Xeroderma Pigmentosum group C (XPC), and X-ray repair cross-complementing groups 1 and 3 (XRCC1 and XRCC3) were analyzed. The studied population included 51 bladder cancer cases and 45 controls. The genotyping of six SNP (single nucleotide polymorphism) was carried out on these populations with the MGB (Minor Groove Binder) probe technique which uses allelic discrimination with the Taqman® method. The Gln allele of the XPC 939 polymorphism was found to be associated with an increase in bladder cancer risk.
ISSN:0250-7005
1791-7530