Clinical significance of energy loss index in patients with low-gradient severe aortic stenosis and preserved ejection fraction

Abstract Aims  We hypothesized that among patients with low-gradient severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF), reclassification of AS severity as moderate by pressure recovery adjusted indexed aortic valve area (AVAi) = energy loss index (ELI), may identify...

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Published in:European heart journal cardiovascular imaging 2020-06, Vol.21 (6), p.608-615
Main Authors: Altes, Alexandre, Ringle, Anne, Bohbot, Yohann, Bouchot, Océane, Appert, Ludovic, Guerbaai, Raphaëlle A, Gun, Mesut, Ennezat, Pierre Vladimir, Tribouilloy, Christophe, Maréchaux, Sylvestre
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Language:English
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Life Sciences
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Summary:Abstract Aims  We hypothesized that among patients with low-gradient severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF), reclassification of AS severity as moderate by pressure recovery adjusted indexed aortic valve area (AVAi) = energy loss index (ELI), may identify a subgroup of patients with a better outcome. Methods and results  Three hundred and seventy-nine patients with low-gradient AS (defined by AVAi ≤ 0.6 cm2/m2 and mean aortic pressure gradient 0.6 cm2/m2. Cardiac events [cardiac mortality and/or need for aortic valve replacement (AVR)] during follow-up were studied. One hundred and forty-eight patients (39%) were reclassified as moderate AS by ELI. Reclassification as moderate AS was independently associated with decreased body surface area, normal flow status, decreased left ventricular mass index, and left atrial volume index (all P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeaa010