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3D printing of biocompatible low molecular weight gels: Imbricated structures with sacrificial and persistent N-alkyl-d-galactonamides
[Display omitted] We have shown earlier that low molecular weight gels based on N-heptyl-d-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. We wanted to explore the printing of less soluble N-alkyl-d-galactonamides with longer alkyl chain...
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Published in: | Journal of colloid and interface science 2022-07, Vol.617, p.156-170 |
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container_title | Journal of colloid and interface science |
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creator | Andriamiseza, Faniry Bordignon, Delphine Payré, Bruno Vaysse, Laurence Fitremann, Juliette |
description | [Display omitted]
We have shown earlier that low molecular weight gels based on N-heptyl-d-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. We wanted to explore the printing of less soluble N-alkyl-d-galactonamides with longer alkyl chains. Less soluble hydrogels could be good candidates as cell culture scaffolds.
N-hexyl, N-octyl and N-nonyl-d-galactonamide solutions in dimethylsulfoxide are injected in a bath of water following patterns driven by a 2D drawing robot coupled to a z-platform. Solubilization of the gels with time has been determined and solubility of the gelators has been measured by NMR. Imbricated structures have been built with N-nonyl-d-galactonamide as a persistent ink and N-hexyl or N-heptyl-d-galactonamide as sacrificial inks. Human mesenchymal stem cells have been cultured on N-nonyl-d-galactonamide hydrogels prepared by cooling or by 3D printing.
The conditions for printing well-resolved 3D patterns have been determined for the three gelators. In imbricated structures, the solubilization of N-hexyl or N-heptyl-d-galactonamide occurred after a few hours or days and gave channels. Human mesenchymal stem cells grown on N-nonyl-d-galactonamide hydrogels prepared by heating–cooling, which are stable and have a fibrillar microstructure, developed properly. 3D printed hydrogels, which microstructure is made of micrometric flakes, appeared too fragile to withstand cell growth. |
doi_str_mv | 10.1016/j.jcis.2022.02.076 |
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We have shown earlier that low molecular weight gels based on N-heptyl-d-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. We wanted to explore the printing of less soluble N-alkyl-d-galactonamides with longer alkyl chains. Less soluble hydrogels could be good candidates as cell culture scaffolds.
N-hexyl, N-octyl and N-nonyl-d-galactonamide solutions in dimethylsulfoxide are injected in a bath of water following patterns driven by a 2D drawing robot coupled to a z-platform. Solubilization of the gels with time has been determined and solubility of the gelators has been measured by NMR. Imbricated structures have been built with N-nonyl-d-galactonamide as a persistent ink and N-hexyl or N-heptyl-d-galactonamide as sacrificial inks. Human mesenchymal stem cells have been cultured on N-nonyl-d-galactonamide hydrogels prepared by cooling or by 3D printing.
The conditions for printing well-resolved 3D patterns have been determined for the three gelators. In imbricated structures, the solubilization of N-hexyl or N-heptyl-d-galactonamide occurred after a few hours or days and gave channels. Human mesenchymal stem cells grown on N-nonyl-d-galactonamide hydrogels prepared by heating–cooling, which are stable and have a fibrillar microstructure, developed properly. 3D printed hydrogels, which microstructure is made of micrometric flakes, appeared too fragile to withstand cell growth.</description><identifier>ISSN: 0021-9797</identifier><identifier>EISSN: 1095-7103</identifier><identifier>DOI: 10.1016/j.jcis.2022.02.076</identifier><identifier>PMID: 35276518</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3D printing ; Additive manufacturing ; Bioprinting ; Biotechnology ; Cell culture ; Cell Culture Techniques ; Chemical Sciences ; Direct ink writing ; Humans ; Hydrogels - chemistry ; Ink ; Life Sciences ; LMWG ; Low molecular mass gel ; Low molecular weight gel ; Material chemistry ; Molecular gel ; Molecular Weight ; Printing, Three-Dimensional ; Self-assembled fibers ; Self-assembly ; Supramolecular ; Tissue Engineering ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of colloid and interface science, 2022-07, Vol.617, p.156-170</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-d1b3634cb7ad279492fad77c6f0a00e847bc6e83d650691ac0339a864b28575f3</citedby><cites>FETCH-LOGICAL-c434t-d1b3634cb7ad279492fad77c6f0a00e847bc6e83d650691ac0339a864b28575f3</cites><orcidid>0000-0002-6784-1125 ; 0000-0002-1080-3742</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35276518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03608642$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Andriamiseza, Faniry</creatorcontrib><creatorcontrib>Bordignon, Delphine</creatorcontrib><creatorcontrib>Payré, Bruno</creatorcontrib><creatorcontrib>Vaysse, Laurence</creatorcontrib><creatorcontrib>Fitremann, Juliette</creatorcontrib><title>3D printing of biocompatible low molecular weight gels: Imbricated structures with sacrificial and persistent N-alkyl-d-galactonamides</title><title>Journal of colloid and interface science</title><addtitle>J Colloid Interface Sci</addtitle><description>[Display omitted]
We have shown earlier that low molecular weight gels based on N-heptyl-d-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. We wanted to explore the printing of less soluble N-alkyl-d-galactonamides with longer alkyl chains. Less soluble hydrogels could be good candidates as cell culture scaffolds.
N-hexyl, N-octyl and N-nonyl-d-galactonamide solutions in dimethylsulfoxide are injected in a bath of water following patterns driven by a 2D drawing robot coupled to a z-platform. Solubilization of the gels with time has been determined and solubility of the gelators has been measured by NMR. Imbricated structures have been built with N-nonyl-d-galactonamide as a persistent ink and N-hexyl or N-heptyl-d-galactonamide as sacrificial inks. Human mesenchymal stem cells have been cultured on N-nonyl-d-galactonamide hydrogels prepared by cooling or by 3D printing.
The conditions for printing well-resolved 3D patterns have been determined for the three gelators. In imbricated structures, the solubilization of N-hexyl or N-heptyl-d-galactonamide occurred after a few hours or days and gave channels. Human mesenchymal stem cells grown on N-nonyl-d-galactonamide hydrogels prepared by heating–cooling, which are stable and have a fibrillar microstructure, developed properly. 3D printed hydrogels, which microstructure is made of micrometric flakes, appeared too fragile to withstand cell growth.</description><subject>3D printing</subject><subject>Additive manufacturing</subject><subject>Bioprinting</subject><subject>Biotechnology</subject><subject>Cell culture</subject><subject>Cell Culture Techniques</subject><subject>Chemical Sciences</subject><subject>Direct ink writing</subject><subject>Humans</subject><subject>Hydrogels - chemistry</subject><subject>Ink</subject><subject>Life Sciences</subject><subject>LMWG</subject><subject>Low molecular mass gel</subject><subject>Low molecular weight gel</subject><subject>Material chemistry</subject><subject>Molecular gel</subject><subject>Molecular Weight</subject><subject>Printing, Three-Dimensional</subject><subject>Self-assembled fibers</subject><subject>Self-assembly</subject><subject>Supramolecular</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - chemistry</subject><issn>0021-9797</issn><issn>1095-7103</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi0EokvhD3BAPsIhiz8SO0FcqvLRSiu4wNma2JNdL0682E5X_QP8brLa0iPSaEYaPe8rzbyEvOZszRlX7_frvfV5LZgQa7aUVk_IirOuqTRn8ilZMSZ41elOX5AXOe8Z47xpuufkQjZCq4a3K_JHfqKH5Kfipy2NA-19tHE8QPF9QBrikY4xoJ0DJHpEv90VusWQP9DbsU_eQkFHc0mzLXPCTI--7GgGm_zgrYdAYXL0gCn7XHAq9FsF4dd9qFy1hQC2xAlG7zC_JM8GCBlfPcxL8vPL5x_XN9Xm-9fb66tNZWtZl8rxXipZ216DE7qrOzGA09qqgQFj2Na6twpb6VTDVMfBMik7aFXdi7bRzSAvybuz7w6CWe4eId2bCN7cXG3MacekYgsv7vjCvj2zhxR_z5iLGX22GAJMGOdshJKtXlqnFlScUZtizgmHR2_OzCkrszenrMwpK8OW0ifRmwf_uR_RPUr-hbMAH8_A8nC885hMth4ni84ntMW46P_n_xdEOKaz</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Andriamiseza, Faniry</creator><creator>Bordignon, Delphine</creator><creator>Payré, Bruno</creator><creator>Vaysse, Laurence</creator><creator>Fitremann, Juliette</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-6784-1125</orcidid><orcidid>https://orcid.org/0000-0002-1080-3742</orcidid></search><sort><creationdate>202207</creationdate><title>3D printing of biocompatible low molecular weight gels: Imbricated structures with sacrificial and persistent N-alkyl-d-galactonamides</title><author>Andriamiseza, Faniry ; Bordignon, Delphine ; Payré, Bruno ; Vaysse, Laurence ; Fitremann, Juliette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-d1b3634cb7ad279492fad77c6f0a00e847bc6e83d650691ac0339a864b28575f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>3D printing</topic><topic>Additive manufacturing</topic><topic>Bioprinting</topic><topic>Biotechnology</topic><topic>Cell culture</topic><topic>Cell Culture Techniques</topic><topic>Chemical Sciences</topic><topic>Direct ink writing</topic><topic>Humans</topic><topic>Hydrogels - chemistry</topic><topic>Ink</topic><topic>Life Sciences</topic><topic>LMWG</topic><topic>Low molecular mass gel</topic><topic>Low molecular weight gel</topic><topic>Material chemistry</topic><topic>Molecular gel</topic><topic>Molecular Weight</topic><topic>Printing, Three-Dimensional</topic><topic>Self-assembled fibers</topic><topic>Self-assembly</topic><topic>Supramolecular</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andriamiseza, Faniry</creatorcontrib><creatorcontrib>Bordignon, Delphine</creatorcontrib><creatorcontrib>Payré, Bruno</creatorcontrib><creatorcontrib>Vaysse, Laurence</creatorcontrib><creatorcontrib>Fitremann, Juliette</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of colloid and interface science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andriamiseza, Faniry</au><au>Bordignon, Delphine</au><au>Payré, Bruno</au><au>Vaysse, Laurence</au><au>Fitremann, Juliette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D printing of biocompatible low molecular weight gels: Imbricated structures with sacrificial and persistent N-alkyl-d-galactonamides</atitle><jtitle>Journal of colloid and interface science</jtitle><addtitle>J Colloid Interface Sci</addtitle><date>2022-07</date><risdate>2022</risdate><volume>617</volume><spage>156</spage><epage>170</epage><pages>156-170</pages><issn>0021-9797</issn><eissn>1095-7103</eissn><abstract>[Display omitted]
We have shown earlier that low molecular weight gels based on N-heptyl-d-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. We wanted to explore the printing of less soluble N-alkyl-d-galactonamides with longer alkyl chains. Less soluble hydrogels could be good candidates as cell culture scaffolds.
N-hexyl, N-octyl and N-nonyl-d-galactonamide solutions in dimethylsulfoxide are injected in a bath of water following patterns driven by a 2D drawing robot coupled to a z-platform. Solubilization of the gels with time has been determined and solubility of the gelators has been measured by NMR. Imbricated structures have been built with N-nonyl-d-galactonamide as a persistent ink and N-hexyl or N-heptyl-d-galactonamide as sacrificial inks. Human mesenchymal stem cells have been cultured on N-nonyl-d-galactonamide hydrogels prepared by cooling or by 3D printing.
The conditions for printing well-resolved 3D patterns have been determined for the three gelators. In imbricated structures, the solubilization of N-hexyl or N-heptyl-d-galactonamide occurred after a few hours or days and gave channels. Human mesenchymal stem cells grown on N-nonyl-d-galactonamide hydrogels prepared by heating–cooling, which are stable and have a fibrillar microstructure, developed properly. 3D printed hydrogels, which microstructure is made of micrometric flakes, appeared too fragile to withstand cell growth.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35276518</pmid><doi>10.1016/j.jcis.2022.02.076</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-6784-1125</orcidid><orcidid>https://orcid.org/0000-0002-1080-3742</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 3D printing Additive manufacturing Bioprinting Biotechnology Cell culture Cell Culture Techniques Chemical Sciences Direct ink writing Humans Hydrogels - chemistry Ink Life Sciences LMWG Low molecular mass gel Low molecular weight gel Material chemistry Molecular gel Molecular Weight Printing, Three-Dimensional Self-assembled fibers Self-assembly Supramolecular Tissue Engineering Tissue Scaffolds - chemistry |
title | 3D printing of biocompatible low molecular weight gels: Imbricated structures with sacrificial and persistent N-alkyl-d-galactonamides |
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