Efficient Synthesis of N-Alkyl Polyhydroxylated Pipecolamide Compounds from d-Glucurono-6,3-lactone

Abstract N -Alkyl pipecolamides were efficiently synthesized from d -glucurono-6,3-lactone via a key 5-azido N -alkylamide intermediate that can be used as a scaffold for the synthesis of 4-amino and N -sulfonated pipecolamide derivatives.

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Bibliographic Details
Published in:Synlett 2017-10, Vol.28 (16), p.2174-2178
Main Authors: Kaddour, Alaa, Toumieux, Sylvestre, Wadouachi, Anne
Format: Article
Language:English
Subjects:
Chemical Sciences
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Summary:Abstract N -Alkyl pipecolamides were efficiently synthesized from d -glucurono-6,3-lactone via a key 5-azido N -alkylamide intermediate that can be used as a scaffold for the synthesis of 4-amino and N -sulfonated pipecolamide derivatives.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1590829