Sustainable Mechanosynthesis of Biologically Active Molecules

Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities of all kinds. This Review is focused on examples reported so far of known Active Pharmaceutical Ingredients (APIs), and effectively eva...

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Bibliographic Details
Published in:European journal of organic chemistry 2022-06, Vol.2022 (21), p.n/a
Main Authors: Bento, Ophélie, Luttringer, Florian, Mohy El Dine, Tharwat, Pétry, Nicolas, Bantreil, Xavier, Lamaty, Frédéric
Format: Article
Language:English
Subjects:
Chemical Sciences
Comminution
Coordination compounds
Extrusion
Grinding mills
Heterocycles
Heterocyclic compounds
Mechanochemistry
Medicinal Chemistry
Metal complexes
Organic chemistry
Peptides
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Summary:Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities of all kinds. This Review is focused on examples reported so far of known Active Pharmaceutical Ingredients (APIs), and effectively evaluated bioactive molecules, all prepared by mechanosynthesis. Three families of molecules are discussed: heterocyclic compounds, metal complexes and peptides. Advantages of the mechanochemistry approach are highlighted especially from a green chemistry and efficacy point of view. Mechanochemistry contributes to the sustainable preparation of molecules in many areas of chemistry. This Review focuses on the mechanosynthesis of known APIs and biologically evaluated new entities (medicinal mechanochemistry), mostly heterocycles, metal complexes, and peptides.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202101516