Cav1 channels is also a story of non excitable cells: Application to calcium signalling in two different non related models

Calcium is a second messenger essential, in all cells, for most cell functions. The spatio-temporal control of changes in intracellular calcium concentration is partly due to the activation of calcium channels. Voltage-operated calcium channels are present in excitable and non-excitable cells. If th...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular cell research 2021-05, Vol.1868 (6), p.118996-118996, Article 118996
Main Authors: Pelletier, Lucette, Moreau, Marc
Format: Article
Language:English
Subjects:
Animals
Ca2+ toolkit
Calcium / metabolism
Calcium Channels, L-Type / genetics
Calcium Channels, L-Type / metabolism
Calcium Signaling
CaV1 channels
Ectoderm / growth & development
Ectoderm / metabolism
Gene Expression Regulation, Developmental
Gene transcription
Immunology
Life Sciences
Neural induction
Th2 Cells / metabolism
Th2 function
Transcription, Genetic
Xenopus laevis / growth & development
Xenopus laevis / metabolism
Xenopus Proteins / genetics
Xenopus Proteins / metabolism
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Summary:Calcium is a second messenger essential, in all cells, for most cell functions. The spatio-temporal control of changes in intracellular calcium concentration is partly due to the activation of calcium channels. Voltage-operated calcium channels are present in excitable and non-excitable cells. If the mechanism of voltage-operated calcium channels is well known in excitable cells the Ca2+ toolkit used in non-excitable cells to activate the calcium channels is less described. Herein we discuss about very similar pathways involving voltage activated Cav1 channels in two unrelated non-excitable cells; ectoderm cells undergoing neural development and effector Th2 lymphocytes responsible for parasite elimination and also allergic diseases. We will examine the way by which these channels operate and are regulated, as well as the consequences in terms of gene transcription. Finally, we will consider the questions that remain unsolved and how they might be a challenge for the future. •Ectoderm cells in embryos and Th2 lymphocytes in adults are non-excitable cells.•Neural fate of ectoderm cells and Th2 functions share a similar Ca2+ toolkit for the transcription of their specific genes.•mechanism of the activation of CaV1 channels in non-excitable cells and the role of other ion channels and kinases
ISSN:0167-4889
1879-2596
DOI:10.1016/j.bbamcr.2021.118996