Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review

Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Pro...

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Bibliographic Details
Published in:Environmental chemistry letters 2022-06, Vol.20 (3), p.2085-2095
Main Authors: Torri, Giangiacomo, Naggi, Annamaria, Lichtfouse, Eric, Crini, Grégorio
Format: Article
Language:English
Subjects:
Analytical Chemistry
Analytical methods
Anticoagulants
Bioavailability
Cages
Chemical Sciences
Conformation
Coordination chemistry
Cyclodextrin
Cyclodextrins
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Sciences
Galenic pharmacology
Geochemistry
Glycosaminoglycans
Heparin
Historical account
Human health and pathology
Hydrophobicity
Infrared spectroscopy
Inorganic chemistry
Life Sciences
Magnetic shielding
Medical sciences
NMR
Nuclear magnetic resonance
Oligosaccharides
Organic chemistry
Pharmaceutical sciences
Pollution
Polysaccharides
Review
Saccharides
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Summary:Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Professor Benito Casu to cyclodextrin research and, more generally, to the chemistry and biochemistry of linear and cyclic oligosaccharides, polysaccharides, glycosaminoglycans, and heparin. Professor Casu was the first to elucidate the structure and conformations of cyclodextrins by infrared spectroscopy and proton nuclear magnetic resonance (NMR). In particular, he showed that trapped compounds induced a shift of H peaks in NMR due to the shielding effect of cyclodextrins. He also demonstrated that the d -glucopyranose cyclodextrin units are in the C-1 chair conformation by analyzing α-cyclodextrin by NMR in dimethylsulfoxide-d 6 .
ISSN:1610-3653
1610-3661
DOI:10.1007/s10311-022-01417-w