Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review

Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Pro...

Full description

Saved in:
Bibliographic Details
Published in:Environmental chemistry letters 2022-06, Vol.20 (3), p.2085-2095
Main Authors: Torri, Giangiacomo, Naggi, Annamaria, Lichtfouse, Eric, Crini, Grégorio
Format: Article
Language:English
Subjects:
Analytical Chemistry
Analytical methods
Anticoagulants
Bioavailability
Cages
Chemical Sciences
Conformation
Coordination chemistry
Cyclodextrin
Cyclodextrins
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Sciences
Galenic pharmacology
Geochemistry
Glycosaminoglycans
Heparin
Historical account
Human health and pathology
Hydrophobicity
Infrared spectroscopy
Inorganic chemistry
Life Sciences
Magnetic shielding
Medical sciences
NMR
Nuclear magnetic resonance
Oligosaccharides
Organic chemistry
Pharmaceutical sciences
Pollution
Polysaccharides
Review
Saccharides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003
cites cdi_FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003
container_end_page 2095
container_issue 3
container_start_page 2085
container_title Environmental chemistry letters
container_volume 20
creator Torri, Giangiacomo
Naggi, Annamaria
Lichtfouse, Eric
Crini, Grégorio
description Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Professor Benito Casu to cyclodextrin research and, more generally, to the chemistry and biochemistry of linear and cyclic oligosaccharides, polysaccharides, glycosaminoglycans, and heparin. Professor Casu was the first to elucidate the structure and conformations of cyclodextrins by infrared spectroscopy and proton nuclear magnetic resonance (NMR). In particular, he showed that trapped compounds induced a shift of H peaks in NMR due to the shielding effect of cyclodextrins. He also demonstrated that the d -glucopyranose cyclodextrin units are in the C-1 chair conformation by analyzing α-cyclodextrin by NMR in dimethylsulfoxide-d 6 .
doi_str_mv 10.1007/s10311-022-01417-w
format article
fullrecord <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03662809v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2665370430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRSMEEuXxA6wssUIiMBMnNmVXVbykSrCAtXGcCQ2kcbGTFnb8Br_Hl-ASVHasZjQ692p0ougA4QQB5KlH4IgxJEkMmKKMlxvRAAVCzIXAzfWe8e1ox_tnCKRMkkH0eOdsSd5bx8bad18fn54Z27Suyru2sg1rLTPvprYFvYVj449ZOyXmaKbdi85rYkY_Ueynek4Fm9maTFeTP2c6MIuKlnvRVqlrT_u_czd6uLy4H1_Hk9urm_FoEhs-lG0sCHiRnfFiKHLUoszJpBJKbgzPUGS5gUwYIzNMU12kuZQyEYS6pFQLNAB8Nzrqe6e6VnNXhf_eldWVuh5N1OoGwURyBsMFBvawZ-fOvnbkW_VsO9eE91QigiMJKV81Jj1lnPXeUbmuRVAr66q3roJL9WNdLUOI9yEf4OaJ3F_1P6lv_MOGcA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2665370430</pqid></control><display><type>article</type><title>Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review</title><source>Springer Link</source><creator>Torri, Giangiacomo ; Naggi, Annamaria ; Lichtfouse, Eric ; Crini, Grégorio</creator><creatorcontrib>Torri, Giangiacomo ; Naggi, Annamaria ; Lichtfouse, Eric ; Crini, Grégorio</creatorcontrib><description>Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Professor Benito Casu to cyclodextrin research and, more generally, to the chemistry and biochemistry of linear and cyclic oligosaccharides, polysaccharides, glycosaminoglycans, and heparin. Professor Casu was the first to elucidate the structure and conformations of cyclodextrins by infrared spectroscopy and proton nuclear magnetic resonance (NMR). In particular, he showed that trapped compounds induced a shift of H peaks in NMR due to the shielding effect of cyclodextrins. He also demonstrated that the d -glucopyranose cyclodextrin units are in the C-1 chair conformation by analyzing α-cyclodextrin by NMR in dimethylsulfoxide-d 6 .</description><identifier>ISSN: 1610-3653</identifier><identifier>EISSN: 1610-3661</identifier><identifier>DOI: 10.1007/s10311-022-01417-w</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Analytical Chemistry ; Analytical methods ; Anticoagulants ; Bioavailability ; Cages ; Chemical Sciences ; Conformation ; Coordination chemistry ; Cyclodextrin ; Cyclodextrins ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Sciences ; Galenic pharmacology ; Geochemistry ; Glycosaminoglycans ; Heparin ; Historical account ; Human health and pathology ; Hydrophobicity ; Infrared spectroscopy ; Inorganic chemistry ; Life Sciences ; Magnetic shielding ; Medical sciences ; NMR ; Nuclear magnetic resonance ; Oligosaccharides ; Organic chemistry ; Pharmaceutical sciences ; Pollution ; Polysaccharides ; Review ; Saccharides</subject><ispartof>Environmental chemistry letters, 2022-06, Vol.20 (3), p.2085-2095</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003</citedby><cites>FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003</cites><orcidid>0000-0002-8535-8073 ; 0000-0003-2540-6851</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03662809$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Torri, Giangiacomo</creatorcontrib><creatorcontrib>Naggi, Annamaria</creatorcontrib><creatorcontrib>Lichtfouse, Eric</creatorcontrib><creatorcontrib>Crini, Grégorio</creatorcontrib><title>Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review</title><title>Environmental chemistry letters</title><addtitle>Environ Chem Lett</addtitle><description>Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Professor Benito Casu to cyclodextrin research and, more generally, to the chemistry and biochemistry of linear and cyclic oligosaccharides, polysaccharides, glycosaminoglycans, and heparin. Professor Casu was the first to elucidate the structure and conformations of cyclodextrins by infrared spectroscopy and proton nuclear magnetic resonance (NMR). In particular, he showed that trapped compounds induced a shift of H peaks in NMR due to the shielding effect of cyclodextrins. He also demonstrated that the d -glucopyranose cyclodextrin units are in the C-1 chair conformation by analyzing α-cyclodextrin by NMR in dimethylsulfoxide-d 6 .</description><subject>Analytical Chemistry</subject><subject>Analytical methods</subject><subject>Anticoagulants</subject><subject>Bioavailability</subject><subject>Cages</subject><subject>Chemical Sciences</subject><subject>Conformation</subject><subject>Coordination chemistry</subject><subject>Cyclodextrin</subject><subject>Cyclodextrins</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Sciences</subject><subject>Galenic pharmacology</subject><subject>Geochemistry</subject><subject>Glycosaminoglycans</subject><subject>Heparin</subject><subject>Historical account</subject><subject>Human health and pathology</subject><subject>Hydrophobicity</subject><subject>Infrared spectroscopy</subject><subject>Inorganic chemistry</subject><subject>Life Sciences</subject><subject>Magnetic shielding</subject><subject>Medical sciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oligosaccharides</subject><subject>Organic chemistry</subject><subject>Pharmaceutical sciences</subject><subject>Pollution</subject><subject>Polysaccharides</subject><subject>Review</subject><subject>Saccharides</subject><issn>1610-3653</issn><issn>1610-3661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRSMEEuXxA6wssUIiMBMnNmVXVbykSrCAtXGcCQ2kcbGTFnb8Br_Hl-ASVHasZjQ692p0ougA4QQB5KlH4IgxJEkMmKKMlxvRAAVCzIXAzfWe8e1ox_tnCKRMkkH0eOdsSd5bx8bad18fn54Z27Suyru2sg1rLTPvprYFvYVj449ZOyXmaKbdi85rYkY_Ueynek4Fm9maTFeTP2c6MIuKlnvRVqlrT_u_czd6uLy4H1_Hk9urm_FoEhs-lG0sCHiRnfFiKHLUoszJpBJKbgzPUGS5gUwYIzNMU12kuZQyEYS6pFQLNAB8Nzrqe6e6VnNXhf_eldWVuh5N1OoGwURyBsMFBvawZ-fOvnbkW_VsO9eE91QigiMJKV81Jj1lnPXeUbmuRVAr66q3roJL9WNdLUOI9yEf4OaJ3F_1P6lv_MOGcA</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Torri, Giangiacomo</creator><creator>Naggi, Annamaria</creator><creator>Lichtfouse, Eric</creator><creator>Crini, Grégorio</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7ST</scope><scope>7UA</scope><scope>7XB</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F1W</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L.G</scope><scope>M2P</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-8535-8073</orcidid><orcidid>https://orcid.org/0000-0003-2540-6851</orcidid></search><sort><creationdate>20220601</creationdate><title>Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review</title><author>Torri, Giangiacomo ; Naggi, Annamaria ; Lichtfouse, Eric ; Crini, Grégorio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analytical Chemistry</topic><topic>Analytical methods</topic><topic>Anticoagulants</topic><topic>Bioavailability</topic><topic>Cages</topic><topic>Chemical Sciences</topic><topic>Conformation</topic><topic>Coordination chemistry</topic><topic>Cyclodextrin</topic><topic>Cyclodextrins</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Sciences</topic><topic>Galenic pharmacology</topic><topic>Geochemistry</topic><topic>Glycosaminoglycans</topic><topic>Heparin</topic><topic>Historical account</topic><topic>Human health and pathology</topic><topic>Hydrophobicity</topic><topic>Infrared spectroscopy</topic><topic>Inorganic chemistry</topic><topic>Life Sciences</topic><topic>Magnetic shielding</topic><topic>Medical sciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oligosaccharides</topic><topic>Organic chemistry</topic><topic>Pharmaceutical sciences</topic><topic>Pollution</topic><topic>Polysaccharides</topic><topic>Review</topic><topic>Saccharides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torri, Giangiacomo</creatorcontrib><creatorcontrib>Naggi, Annamaria</creatorcontrib><creatorcontrib>Lichtfouse, Eric</creatorcontrib><creatorcontrib>Crini, Grégorio</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Agriculture &amp; Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 3: Aquatic Pollution &amp; Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Materials Science Database</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Environmental chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torri, Giangiacomo</au><au>Naggi, Annamaria</au><au>Lichtfouse, Eric</au><au>Crini, Grégorio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review</atitle><jtitle>Environmental chemistry letters</jtitle><stitle>Environ Chem Lett</stitle><date>2022-06-01</date><risdate>2022</risdate><volume>20</volume><issue>3</issue><spage>2085</spage><epage>2095</epage><pages>2085-2095</pages><issn>1610-3653</issn><eissn>1610-3661</eissn><abstract>Cyclodextrins are cage-shaped molecules having the remarkable ability to trap smaller compounds, and have thus led to applications in many disciplines such as medicine to increase the bioavailability of hydrophobic drugs. This historical review summarizes the outstanding contribution of the late Professor Benito Casu to cyclodextrin research and, more generally, to the chemistry and biochemistry of linear and cyclic oligosaccharides, polysaccharides, glycosaminoglycans, and heparin. Professor Casu was the first to elucidate the structure and conformations of cyclodextrins by infrared spectroscopy and proton nuclear magnetic resonance (NMR). In particular, he showed that trapped compounds induced a shift of H peaks in NMR due to the shielding effect of cyclodextrins. He also demonstrated that the d -glucopyranose cyclodextrin units are in the C-1 chair conformation by analyzing α-cyclodextrin by NMR in dimethylsulfoxide-d 6 .</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10311-022-01417-w</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8535-8073</orcidid><orcidid>https://orcid.org/0000-0003-2540-6851</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1610-3653
ispartof Environmental chemistry letters, 2022-06, Vol.20 (3), p.2085-2095
issn 1610-3653
1610-3661
language eng
recordid cdi_hal_primary_oai_HAL_hal_03662809v1
source Springer Link
subjects Analytical Chemistry
Analytical methods
Anticoagulants
Bioavailability
Cages
Chemical Sciences
Conformation
Coordination chemistry
Cyclodextrin
Cyclodextrins
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Sciences
Galenic pharmacology
Geochemistry
Glycosaminoglycans
Heparin
Historical account
Human health and pathology
Hydrophobicity
Infrared spectroscopy
Inorganic chemistry
Life Sciences
Magnetic shielding
Medical sciences
NMR
Nuclear magnetic resonance
Oligosaccharides
Organic chemistry
Pharmaceutical sciences
Pollution
Polysaccharides
Review
Saccharides
title Professor Casu’s contribution to cyclodextrins, the remarkable cage-shaped molecules: a review
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T00%3A23%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Professor%20Casu%E2%80%99s%20contribution%20to%20cyclodextrins,%20the%20remarkable%20cage-shaped%20molecules:%20a%20review&rft.jtitle=Environmental%20chemistry%20letters&rft.au=Torri,%20Giangiacomo&rft.date=2022-06-01&rft.volume=20&rft.issue=3&rft.spage=2085&rft.epage=2095&rft.pages=2085-2095&rft.issn=1610-3653&rft.eissn=1610-3661&rft_id=info:doi/10.1007/s10311-022-01417-w&rft_dat=%3Cproquest_hal_p%3E2665370430%3C/proquest_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c397t-6e03d583d96b1a6fbec470f3cc35165bc056cc75144ad4b77726e1afe4a61c003%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2665370430&rft_id=info:pmid/&rfr_iscdi=true