Antiarrhythmic Effect of Statin Therapy and Atrial Fibrillation

Antiarrhythmic Effect of Statin Therapy and Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials Laurent Fauchier, Bertrand Pierre, Axel de Labriolle, Caroline Grimard, Noura Zannad, Dominique Babuty A systematic review of randomized controlled trials with statins was performed with...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-02, Vol.51 (8), p.828-835
Main Authors: Fauchier, Laurent, MD, PhD, Pierre, Bertrand, MD, de Labriolle, Axel, MD, Grimard, Caroline, MD, Zannad, Noura, MD, Babuty, Dominique, MD, PhD
Format: Article
Language:English
Subjects:
Cardiovascular
Humanities and Social Sciences
Internal Medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antiarrhythmic Effect of Statin Therapy and Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials Laurent Fauchier, Bertrand Pierre, Axel de Labriolle, Caroline Grimard, Noura Zannad, Dominique Babuty A systematic review of randomized controlled trials with statins was performed with analysis on the end point of incidence or recurrence of atrial fibrillation (AF). Six studies with 3,557 patients in sinus rhythm were included in this analysis. Incidence or recurrence of AF occurred in 386 patients. Overall, the use of statins was significantly associated with a decreased risk of AF compared with control (odds ratio [OR] 0.39, 95% confidence interval 0.18 to 0.85, p = 0.02). Benefit of statin therapy seemed more marked in secondary prevention of AF (OR 0.33, p = 0.06) than for new-onset or postoperative AF (OR 0.60, p = 0.23).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.09.063