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Screening platelet function in blood donors

Background Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding. Study Design and Methods This single‐center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood...

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Published in:Transfusion (Philadelphia, Pa.) Pa.), 2022-08, Vol.62 (8), p.1643-1651
Main Authors: Pedini, Pascal, Baudey, Jean‐Baptiste, Pouymayou, Katia, Falaise, Celine, Ibrahim‐Kosta, Manal, Vélier, Melanie, Demerle, Clémence, Graiet, Hajer, Dragutini, Catherine, Dombey, Anne‐marie, Chiaroni, Jacques, Alessi, Marie Christine, Picard, Christophe
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cited_by cdi_FETCH-LOGICAL-c3990-5c249f04ac4de1d4462d492aaa54cd08a994a7d10744fd943e7164be9bd1d4043
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container_issue 8
container_start_page 1643
container_title Transfusion (Philadelphia, Pa.)
container_volume 62
creator Pedini, Pascal
Baudey, Jean‐Baptiste
Pouymayou, Katia
Falaise, Celine
Ibrahim‐Kosta, Manal
Vélier, Melanie
Demerle, Clémence
Graiet, Hajer
Dragutini, Catherine
Dombey, Anne‐marie
Chiaroni, Jacques
Alessi, Marie Christine
Picard, Christophe
description Background Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding. Study Design and Methods This single‐center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood donors with a clinical history of bleeding diathesis or with history of hematoma (>4 cm) during blood donation. Donors with positive bleeding screening questionnaire were referred to the reference center for rare platelet diseases at La Timone University Hospital (Marseille) to confirm the bleeding tendency using a more extensive bleeding questionnaire (MCMDMscore) and to assess hemostasis, including a comprehensive platelet analysis. Results One hundred and ninety‐five donors identified based on a history of hematoma and 2434 blood donors were included in the study. Eighty‐eight donors (3.6%) had a bleeding score indicating a potential bleeding disorder. Five donors with a history of hematoma (2.5%) and 15 (17%) donors with a confirmed bleeding score underwent hemostatic analysis, including two men and 18 women with average age of 33.9 years. Minor hemostatic abnormalities were observed in three donors. Two donors exhibited accelerated fibrinolysis with reduced euglobulin lysis time and increased D‐dimer levels in serum. Two donors had a platelet granule defect, without identification of genetic abnormality. Conclusion The bleeding questionnaire proved to be a valuable tool to screen blood donors for potential platelet defects. Platelet dysfunction was rare in the blood donor population assessed. Additional studies are necessary to understand the clinical impact that the transfusion of platelets with qualitative defects has on recipients.
doi_str_mv 10.1111/trf.16990
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Study Design and Methods This single‐center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood donors with a clinical history of bleeding diathesis or with history of hematoma (&gt;4 cm) during blood donation. Donors with positive bleeding screening questionnaire were referred to the reference center for rare platelet diseases at La Timone University Hospital (Marseille) to confirm the bleeding tendency using a more extensive bleeding questionnaire (MCMDMscore) and to assess hemostasis, including a comprehensive platelet analysis. Results One hundred and ninety‐five donors identified based on a history of hematoma and 2434 blood donors were included in the study. Eighty‐eight donors (3.6%) had a bleeding score indicating a potential bleeding disorder. Five donors with a history of hematoma (2.5%) and 15 (17%) donors with a confirmed bleeding score underwent hemostatic analysis, including two men and 18 women with average age of 33.9 years. Minor hemostatic abnormalities were observed in three donors. Two donors exhibited accelerated fibrinolysis with reduced euglobulin lysis time and increased D‐dimer levels in serum. Two donors had a platelet granule defect, without identification of genetic abnormality. Conclusion The bleeding questionnaire proved to be a valuable tool to screen blood donors for potential platelet defects. Platelet dysfunction was rare in the blood donor population assessed. Additional studies are necessary to understand the clinical impact that the transfusion of platelets with qualitative defects has on recipients.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.16990</identifier><identifier>PMID: 35748562</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Abnormalities ; Bleeding ; Blood ; Blood &amp; organ donations ; blood donor ; Blood donors ; Blood platelets ; Blood transfusion ; Defects ; Fibrinolysis ; Hematoma ; Hemostasis ; hemostatic disorder ; Hemostatics ; Life Sciences ; Lysis ; platelet ; Platelets ; Population studies ; prevalence ; Questionnaires ; Screening ; Transfusion</subject><ispartof>Transfusion (Philadelphia, Pa.), 2022-08, Vol.62 (8), p.1643-1651</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of AABB.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3990-5c249f04ac4de1d4462d492aaa54cd08a994a7d10744fd943e7164be9bd1d4043</citedby><cites>FETCH-LOGICAL-c3990-5c249f04ac4de1d4462d492aaa54cd08a994a7d10744fd943e7164be9bd1d4043</cites><orcidid>0000-0001-9299-3705 ; 0000-0002-3133-8990</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03705360$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedini, Pascal</creatorcontrib><creatorcontrib>Baudey, Jean‐Baptiste</creatorcontrib><creatorcontrib>Pouymayou, Katia</creatorcontrib><creatorcontrib>Falaise, Celine</creatorcontrib><creatorcontrib>Ibrahim‐Kosta, Manal</creatorcontrib><creatorcontrib>Vélier, Melanie</creatorcontrib><creatorcontrib>Demerle, Clémence</creatorcontrib><creatorcontrib>Graiet, Hajer</creatorcontrib><creatorcontrib>Dragutini, Catherine</creatorcontrib><creatorcontrib>Dombey, Anne‐marie</creatorcontrib><creatorcontrib>Chiaroni, Jacques</creatorcontrib><creatorcontrib>Alessi, Marie Christine</creatorcontrib><creatorcontrib>Picard, Christophe</creatorcontrib><title>Screening platelet function in blood donors</title><title>Transfusion (Philadelphia, Pa.)</title><description>Background Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding. Study Design and Methods This single‐center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood donors with a clinical history of bleeding diathesis or with history of hematoma (&gt;4 cm) during blood donation. Donors with positive bleeding screening questionnaire were referred to the reference center for rare platelet diseases at La Timone University Hospital (Marseille) to confirm the bleeding tendency using a more extensive bleeding questionnaire (MCMDMscore) and to assess hemostasis, including a comprehensive platelet analysis. Results One hundred and ninety‐five donors identified based on a history of hematoma and 2434 blood donors were included in the study. Eighty‐eight donors (3.6%) had a bleeding score indicating a potential bleeding disorder. Five donors with a history of hematoma (2.5%) and 15 (17%) donors with a confirmed bleeding score underwent hemostatic analysis, including two men and 18 women with average age of 33.9 years. Minor hemostatic abnormalities were observed in three donors. Two donors exhibited accelerated fibrinolysis with reduced euglobulin lysis time and increased D‐dimer levels in serum. Two donors had a platelet granule defect, without identification of genetic abnormality. Conclusion The bleeding questionnaire proved to be a valuable tool to screen blood donors for potential platelet defects. Platelet dysfunction was rare in the blood donor population assessed. Additional studies are necessary to understand the clinical impact that the transfusion of platelets with qualitative defects has on recipients.</description><subject>Abnormalities</subject><subject>Bleeding</subject><subject>Blood</subject><subject>Blood &amp; organ donations</subject><subject>blood donor</subject><subject>Blood donors</subject><subject>Blood platelets</subject><subject>Blood transfusion</subject><subject>Defects</subject><subject>Fibrinolysis</subject><subject>Hematoma</subject><subject>Hemostasis</subject><subject>hemostatic disorder</subject><subject>Hemostatics</subject><subject>Life Sciences</subject><subject>Lysis</subject><subject>platelet</subject><subject>Platelets</subject><subject>Population studies</subject><subject>prevalence</subject><subject>Questionnaires</subject><subject>Screening</subject><subject>Transfusion</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp10E1LAzEQBuAgiq3Vg_9gwYsi206-dpujFGuFgqD1HNJNVrekSU12lf57UysKgrkMhGeSmRehcwxDnM6oDfUQF0LAAepjTsucCMEPUR-A4RxjSnroJMYVABAB-Bj1KC_ZmBekj66fqmCMa9xLtrGqNda0Wd25qm28yxqXLa33OtPe-RBP0VGtbDRn33WAnqe3i8ksnz_c3U9u5nlF0ww5rwgTNTBVMW2wZqwgmgmilOKs0jBWQjBVagwlY7UWjJoSF2xpxFInDYwO0NX-3Vdl5SY0axW20qtGzm7mcncHtAROC3jHyV7u7Sb4t87EVq6bWBlrlTO-i5IUYwyUU0wTvfhDV74LLm2SlBCYChDk9_Mq-BiDqX8mwCB3acuUtvxKO9nR3n401mz_h3LxON13fAITOHvm</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Pedini, Pascal</creator><creator>Baudey, Jean‐Baptiste</creator><creator>Pouymayou, Katia</creator><creator>Falaise, Celine</creator><creator>Ibrahim‐Kosta, Manal</creator><creator>Vélier, Melanie</creator><creator>Demerle, Clémence</creator><creator>Graiet, Hajer</creator><creator>Dragutini, Catherine</creator><creator>Dombey, Anne‐marie</creator><creator>Chiaroni, Jacques</creator><creator>Alessi, Marie Christine</creator><creator>Picard, Christophe</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>24P</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9299-3705</orcidid><orcidid>https://orcid.org/0000-0002-3133-8990</orcidid></search><sort><creationdate>202208</creationdate><title>Screening platelet function in blood donors</title><author>Pedini, Pascal ; Baudey, Jean‐Baptiste ; Pouymayou, Katia ; Falaise, Celine ; Ibrahim‐Kosta, Manal ; Vélier, Melanie ; Demerle, Clémence ; Graiet, Hajer ; Dragutini, Catherine ; Dombey, Anne‐marie ; Chiaroni, Jacques ; Alessi, Marie Christine ; Picard, Christophe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3990-5c249f04ac4de1d4462d492aaa54cd08a994a7d10744fd943e7164be9bd1d4043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abnormalities</topic><topic>Bleeding</topic><topic>Blood</topic><topic>Blood &amp; organ donations</topic><topic>blood donor</topic><topic>Blood donors</topic><topic>Blood platelets</topic><topic>Blood transfusion</topic><topic>Defects</topic><topic>Fibrinolysis</topic><topic>Hematoma</topic><topic>Hemostasis</topic><topic>hemostatic disorder</topic><topic>Hemostatics</topic><topic>Life Sciences</topic><topic>Lysis</topic><topic>platelet</topic><topic>Platelets</topic><topic>Population studies</topic><topic>prevalence</topic><topic>Questionnaires</topic><topic>Screening</topic><topic>Transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedini, Pascal</creatorcontrib><creatorcontrib>Baudey, Jean‐Baptiste</creatorcontrib><creatorcontrib>Pouymayou, Katia</creatorcontrib><creatorcontrib>Falaise, Celine</creatorcontrib><creatorcontrib>Ibrahim‐Kosta, Manal</creatorcontrib><creatorcontrib>Vélier, Melanie</creatorcontrib><creatorcontrib>Demerle, Clémence</creatorcontrib><creatorcontrib>Graiet, Hajer</creatorcontrib><creatorcontrib>Dragutini, Catherine</creatorcontrib><creatorcontrib>Dombey, Anne‐marie</creatorcontrib><creatorcontrib>Chiaroni, Jacques</creatorcontrib><creatorcontrib>Alessi, Marie Christine</creatorcontrib><creatorcontrib>Picard, Christophe</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedini, Pascal</au><au>Baudey, Jean‐Baptiste</au><au>Pouymayou, Katia</au><au>Falaise, Celine</au><au>Ibrahim‐Kosta, Manal</au><au>Vélier, Melanie</au><au>Demerle, Clémence</au><au>Graiet, Hajer</au><au>Dragutini, Catherine</au><au>Dombey, Anne‐marie</au><au>Chiaroni, Jacques</au><au>Alessi, Marie Christine</au><au>Picard, Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening platelet function in blood donors</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><date>2022-08</date><risdate>2022</risdate><volume>62</volume><issue>8</issue><spage>1643</spage><epage>1651</epage><pages>1643-1651</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>Background Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding. Study Design and Methods This single‐center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood donors with a clinical history of bleeding diathesis or with history of hematoma (&gt;4 cm) during blood donation. Donors with positive bleeding screening questionnaire were referred to the reference center for rare platelet diseases at La Timone University Hospital (Marseille) to confirm the bleeding tendency using a more extensive bleeding questionnaire (MCMDMscore) and to assess hemostasis, including a comprehensive platelet analysis. Results One hundred and ninety‐five donors identified based on a history of hematoma and 2434 blood donors were included in the study. Eighty‐eight donors (3.6%) had a bleeding score indicating a potential bleeding disorder. Five donors with a history of hematoma (2.5%) and 15 (17%) donors with a confirmed bleeding score underwent hemostatic analysis, including two men and 18 women with average age of 33.9 years. Minor hemostatic abnormalities were observed in three donors. Two donors exhibited accelerated fibrinolysis with reduced euglobulin lysis time and increased D‐dimer levels in serum. Two donors had a platelet granule defect, without identification of genetic abnormality. Conclusion The bleeding questionnaire proved to be a valuable tool to screen blood donors for potential platelet defects. Platelet dysfunction was rare in the blood donor population assessed. Additional studies are necessary to understand the clinical impact that the transfusion of platelets with qualitative defects has on recipients.</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>35748562</pmid><doi>10.1111/trf.16990</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9299-3705</orcidid><orcidid>https://orcid.org/0000-0002-3133-8990</orcidid><oa>free_for_read</oa></addata></record>
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subjects Abnormalities
Bleeding
Blood
Blood & organ donations
blood donor
Blood donors
Blood platelets
Blood transfusion
Defects
Fibrinolysis
Hematoma
Hemostasis
hemostatic disorder
Hemostatics
Life Sciences
Lysis
platelet
Platelets
Population studies
prevalence
Questionnaires
Screening
Transfusion
title Screening platelet function in blood donors
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