Brain imaging determinants of functional prognosis after severe endocarditis: a multicenter observational study

• Published in: Neurological sciences 2022-06, Vol.43 (6), p.3759-3768
• Main Authors: Guettard, Yves-Olivier, Gros, Alexandre, Fukutomi, Hikaru, Pillois, Xavier, Préau, Sebastien, Lavie-Badie, Yoan, Marest, Delphine, Martins, Raphaël P., Coupez, Elisabeth, Coudroy, Rémi, Seguy, Benjamin, Boyer, Alexandre, Tourdias, Thomas
• Format: Article
• Language: English
• Subjects: Bioengineering; Brain - diagnostic imaging; Brain - pathology; Endocarditis; Endocarditis - complications; Endocarditis - diagnostic imaging; Endocarditis, Bacterial - complications; Endocarditis, Bacterial - diagnostic imaging; Heart surgery; Hemorrhage; Humans; Intensive care units; Ischemia; Lesions; Life Sciences; Medicine; Medicine & Public Health; Nervous System Diseases - complications; Neuroimaging; Neurological complications; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Observational studies; Original Article; Patients; Phenotypes; Prognosis; Psychiatry; Risk Factors; Treatment Outcome
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-021-05789-9

Objective We developed a detailed imaging phenotype of the cerebral complications in critically ill patients with infective endocarditis (IE) and determine whether any specific imaging pattern could impact prognostic information. Methods One hundred ninety-two patients admitted to the intensive care units of seven tertiary centers with severe, definite left IE and neurological complications were included. All underwent cerebral imaging few days after admission to define the types of lesions, their volumes, and their locations using voxel-based lesion-symptom mapping (VLSM). We employed uni- and multi-variate logistic regression analyses to explore the associations among imaging features and other prognostic variables and the 6-month modified Rankin Scale (mRS) score. Results Ischemic lesions were the most common lesions (75%; mean volume, 15.3 ± 33 mL) followed by microbleeds (50%; mean number, 4 ± 7.5), subarachnoidal hemorrhages (20%), hemorrhagic strokes (16%; mean volume, 14.6 ± 21 mL), and hemorrhagic transformations (10%; mean volume, 5.6 ± 11 mL). The volume of hemorrhagic transformations, the severity of leukopathy, and the compromises of certain locations on the motor pathway from the VLSM were associated with a poor 6-month mRS score on univariate analyses. However, upon multivariate analyses, no such specific imaging pattern independently predicted the mRS; this was instead influenced principally by age (OR = 1.03 [1.004–1.06]) and cardiac surgery status (OR = 0.06 [0.02–0.16]) in the entire cohort, and by age (OR = 1.04 [1.01–1.08]) and Staphylococcus aureus status (OR = 2.86 [1.19–6.89]) in operated patients. Conclusions In a cohort of severely ill IE patients with neurological complications, no specific imaging pattern could be highlighted as a reliable predictor of prognosis.