Odorant Metabolism in Humans

Odorants are relatively small molecules which are easily taken up and distributed in the human body. Despite their relevance in everyday life, however, only a limited amount of evidence about their metabolism, pathways, and bioactivities in the human body exists. With this Review, we aim to encourag...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-08, Vol.61 (35), p.e202202866-n/a
Main Authors: Kornbausch, Nicole, Debong, Marcel W., Buettner, Andrea, Heydel, Jean‐Marie, Loos, Helene M.
Format: Article
Language:English
Subjects:
Aroma compounds
Biotransformation
Chemical Sciences
Enzymes
Flavor
Food and Nutrition
Gastrointestinal system
Gastrointestinal tract
Human body
Inhibitors
Interdisciplinary research
Interdisciplinary studies
Life Sciences
Odorants
Olfaction
Oral cavity
Respiratory tract
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Summary:Odorants are relatively small molecules which are easily taken up and distributed in the human body. Despite their relevance in everyday life, however, only a limited amount of evidence about their metabolism, pathways, and bioactivities in the human body exists. With this Review, we aim to encourage future interdisciplinary research on the function and mechanisms of the biotransformation of odorants, involving different disciplines such as nutrition, medicine, biochemistry, chemistry, and sensory sciences. Starting with a general overview of the different ways of odorant uptake and enzymes involved in the metabolism of odorants, a more precise description of biotransformation processes and their function in the oral cavity, the nose, the lower respiratory tract (LRT), and the gastrointestinal tract (GIT) is given together with an overview of the different routes of odorant excretion. Finally, perspectives for future research are discussed. The complete passage and turnover of odorants within the human organism, beginning with the various routes of odorant uptake, followed by biotransformation and excretion are delineated in this Review. Special emphasis is placed on a comparison of the involved enzymes concerning the nasal, oral, respiratory tract and gastrointestinal metabolism of odorants and the respective functions of odorant metabolism in these body sites.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202202866