Recurrent glioblastomas in the elderly after maximal first-line treatment: does preserved overall condition warrant a maximal second-line treatment?

A growing literature supports maximal safe resection followed by standard combined chemoradiotherapy (i.e. maximal first-line therapy) for selected elderly glioblastoma patients. To assess the prognostic factors from recurrence in elderly glioblastoma patients treated by maximal safe resection follo...

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Bibliographic Details
Published in:Journal of neuro-oncology 2017-11, Vol.135 (2), p.285-297
Main Authors: Zanello, Marc, Roux, Alexandre, Ursu, Renata, Peeters, Sophie, Bauchet, Luc, Noel, Georges, Guyotat, Jacques, Le Reste, Pierre-Jean, Faillot, Thierry, Litre, Fabien, Desse, Nicolas, Emery, Evelyne, Petit, Antoine, Peltier, Johann, Voirin, Jimmy, Caire, François, Barat, Jean-Luc, Vignes, Jean-Rodolphe, Menei, Philippe, Langlois, Olivier, Dezamis, Edouard, Carpentier, Antoine, Dam Hieu, Phong, Metellus, Philippe, Pallud, Johan
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Angiogenesis
Bevacizumab
Brain Neoplasms - therapy
Chemoradiotherapy
Chemotherapy
Clinical Study
Combined Modality Therapy
Computer Science
Female
Follow-Up Studies
Geriatrics
Glioblastoma
Glioblastoma - therapy
Humans
Image Processing
Karnofsky Performance Status
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Monoclonal antibodies
Multivariate Analysis
Neoplasm Recurrence, Local - therapy
Neurology
Oncology
Prognosis
Retrospective Studies
Surgery
Survival
Survival Analysis
Targeted cancer therapy
Temozolomide
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Summary:A growing literature supports maximal safe resection followed by standard combined chemoradiotherapy (i.e. maximal first-line therapy) for selected elderly glioblastoma patients. To assess the prognostic factors from recurrence in elderly glioblastoma patients treated by maximal safe resection followed by standard combined chemoradiotherapy as first-line therapy. Multicentric retrospective analysis comparing the prognosis and optimal oncological management of recurrent glioblastomas between 660 adult patients aged of
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-017-2573-y