Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and coencapsulation of actives

In this study, Pickering emulsions of dodecane and medium chain triglyceride (MCT) oils were stabilized by simply alkylated-dextran nanoparticles. Our findings show that very little of these bio-friendly nanoparticles is necessary to stabilize Pickering emulsions while providing a high time stabilit...

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Published in:Carbohydrate polymers 2022-05, Vol.284
Main Authors: Maingret, Valentin, Chartier, Coraline, Six, Jean-Luc, Schmitt, Véronique, Héroguez, Valérie
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Language:English
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Chemical Sciences
Material chemistry
Polymers
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container_title Carbohydrate polymers
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creator Maingret, Valentin
Chartier, Coraline
Six, Jean-Luc
Schmitt, Véronique
Héroguez, Valérie
description In this study, Pickering emulsions of dodecane and medium chain triglyceride (MCT) oils were stabilized by simply alkylated-dextran nanoparticles. Our findings show that very little of these bio-friendly nanoparticles is necessary to stabilize Pickering emulsions while providing a high time stability (more than a year at 37°C). As dextran is known to be cleavable by dextranase enzyme, hydrolysis of the nanoparticles in the presence of dextranase could be achieved. This allowed performing on-demand destabilization of Pickering emulsions. Furthermore, two different fluorescent probes were loaded into the stabilizing particles and the oil droplets respectively, providing a proof of concept for co-encapsulation of actives in advanced delivery applications. Additionally, to a conventional fluorescence probe, quinine, an antimalarial drug was also encapsulated into the nanoparticles.
doi_str_mv 10.1016/j.carbpol.2022.119146
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subjects Chemical Sciences
Material chemistry
Polymers
title Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and coencapsulation of actives
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