Synthesis of indoles through acceptorless dehydrogenative coupling catalyzed by nickel on silica-alumina

[Display omitted] The high atom-economical formation of indoles from anilines and diols was described with affordable and easy to handle Ni/SiO2-Al2O3. After optimization, 2,3-dimethylindole was isolated with an excellent 98% yield in neat conditions. The scope of the reaction was studied and 13 ind...

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Bibliographic Details
Published in:Tetrahedron letters 2021-08, Vol.78, p.153270, Article 153270
Main Authors: Charvieux, Aubin, Hammoud, Abdul Aziz, Duclos, Marie-Christine, Duguet, Nicolas, Métay, Estelle
Format: Article
Language:English
Subjects:
Acceptorless dehydrogenative coupling
Anilines
Catalysis
Chemical Sciences
Diols
Heterogeneous nickel
Indole
Organic chemistry
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Summary:[Display omitted] The high atom-economical formation of indoles from anilines and diols was described with affordable and easy to handle Ni/SiO2-Al2O3. After optimization, 2,3-dimethylindole was isolated with an excellent 98% yield in neat conditions. The scope of the reaction was studied and 13 indoles were isolated in 16–80% yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153270