The neurobehavioral effects of the designer drug naphyrone – an experimental investigation with pharmacokinetics and concentration/effect relationship in mice

Rationale The recreational use of naphyrone, a potent synthetic cathinone with a pyrovalerone structure, has raised questions about possible deleterious neurobehavioral consequences. Objective To investigate naphyrone-induced neurobehavioral effects and alterations in brain monoamines using two patt...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacology 2020-07, Vol.237 (7), p.1943-1957
Main Authors: Mégarbane, Bruno, Gamblin, Camille, Roussel, Olivier, Bouaziz-Amar, Elodie, Chevillard, Lucie, Callebert, Jacques, Chen, Huixiong, Morineau, Gilles, Laplanche, Jean-Louis, Etheve-Quelquejeu, Mélanie, Liechti, Matthias E., Benturquia, Nadia
Format: Article
Language:English
Subjects:
Abuse
Anxiety
Behavior
Behavioral despair
Biomedical and Life Sciences
Biomedicine
Dopamine
Hedonic response
Injection
Life Sciences
Locomotor activity
Monoamines
Neurosciences
Norepinephrine
Original Investigation
Pharmacokinetics
Pharmacology/Toxicology
Prefrontal cortex
Psychiatry
Serotonin
Social interaction
Spatial memory
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rationale The recreational use of naphyrone, a potent synthetic cathinone with a pyrovalerone structure, has raised questions about possible deleterious neurobehavioral consequences. Objective To investigate naphyrone-induced neurobehavioral effects and alterations in brain monoamines using two patterns of abuse, i.e., single and repeated (binge) use. Methods We studied naphyrone dose/induced locomotor activity relationship at 3, 10, 30, and 100 mg/kg in mice. We investigated the effects of single (30 mg/kg; acute injection) versus repeated (30 mg/kg ×3/day for 3 days; binge injection) intraperitoneal naphyrone administration on locomotor activity, anxiety-like behavior, spatial recognition memory, anhedonia, behavioral despair, and social interaction. We measured post-mortem prefrontal cortex levels of monoamines and modeled naphyrone pharmacokinetics and concentration/locomotor effect relationship. Results Both naphyrone administration patterns induced time-dependent increases in locomotor activity ( p  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-020-05510-2