CSB-Dependent Cyclin-Dependent Kinase 9 Degradation and RNA Polymerase II Phosphorylation during Transcription-Coupled Repair

DNA lesions block cellular processes such as transcription, inducing apoptosis, tissue failures, and premature aging. To counteract the deleterious effects of DNA damage, cells are equipped with various DNA repair pathways.

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Bibliographic Details
Published in:Molecular and cellular biology 2019-03, Vol.39 (6)
Main Authors: Donnio, Lise-Marie, Lagarou, Anna, Sueur, Gabrielle, Mari, Pierre-Olivier, Giglia-Mari, Giuseppina
Format: Article
Language:English
Subjects:
Life Sciences
Online Access:Get full text
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Description
Summary:DNA lesions block cellular processes such as transcription, inducing apoptosis, tissue failures, and premature aging. To counteract the deleterious effects of DNA damage, cells are equipped with various DNA repair pathways.
ISSN:0270-7306
1098-5549
DOI:10.1128/mcb.00225-18