Eukaryotic cellular intricacies shape mitochondrial proteomic complexity

Mitochondria have been fundamental to the eco‐physiological success of eukaryotes since the last eukaryotic common ancestor (LECA). They contribute essential functions to eukaryotic cells, above and beyond classical respiration. Mitochondria interact with, and complement, metabolic pathways occurrin...

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Bibliographic Details
Published in:BioEssays 2022-05, Vol.44 (5), p.e2100258-n/a
Main Authors: Hammond, Michael, Dorrell, Richard G., Speijer, Dave, Lukeš, Julius
Format: Article
Language:English
Subjects:
Biological Evolution
Cellular Biology
Chloroplasts
Complexity
Eukaryota - physiology
Eukaryotes
Eukaryotic Cells - metabolism
Evolution
Life Sciences
mass spectrometry
Metabolic pathways
Metabolism
Mitochondria
Mitochondria - metabolism
mitoproteome
multicellularity
Organelles
Organelles - metabolism
parasite
Photosynthesis
Phylogeny
plastid
Proteomics
protist
Subcellular Processes
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Summary:Mitochondria have been fundamental to the eco‐physiological success of eukaryotes since the last eukaryotic common ancestor (LECA). They contribute essential functions to eukaryotic cells, above and beyond classical respiration. Mitochondria interact with, and complement, metabolic pathways occurring in other organelles, notably diversifying the chloroplast metabolism of photosynthetic organisms. Here, we integrate existing literature to investigate how mitochondrial metabolism varies across the landscape of eukaryotic evolution. We illustrate the mitochondrial remodelling and proteomic changes undergone in conjunction with major evolutionary transitions. We explore how the mitochondrial complexity of the LECA has been remodelled in specific groups to support subsequent evolutionary transitions, such as the acquisition of chloroplasts in photosynthetic species and the emergence of multicellularity. We highlight the versatile and crucial roles played by mitochondria during eukaryotic evolution, extending from its huge contribution to the development of the LECA itself to the dynamic evolution of individual eukaryote groups, reflecting both their current ecologies and evolutionary histories. Existing literature was integrated to investigate how mitochondrial metabolism varies across the landscape of eukaryotic evolution. The mitochondrial remodelling and proteomic changes undergone in conjunction with major evolutionary transitions, across multicellular plants and animals, as well as a variety of protist lineages of various lifestyles, was illustrated.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.202100258