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Surfactant micelle self-assembly directed highly symmetric ultrasmall inorganic cages

Nanoscale objects with highly symmetrical cage-like polyhedral shapes, often with icosahedral symmetry, have recently been assembled using DNA 1-3 , RNA 4 , and proteins 5,6 for biomedical applications. These achievements relied on advances in the development of programmable self-assembling biomater...

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Bibliographic Details
Published in:Nature (London) 2018-06, Vol.558, p.577-580
Main Authors: Ma, Kai, Gong, Yunye, Aubert, Tangi, Turker, Melik, Kao, Teresa, Doerschuk, Peter, Wiesner, Ulrich
Format: Article
Language:English
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Summary:Nanoscale objects with highly symmetrical cage-like polyhedral shapes, often with icosahedral symmetry, have recently been assembled using DNA 1-3 , RNA 4 , and proteins 5,6 for biomedical applications. These achievements relied on advances in the development of programmable self-assembling biomaterials 7-10 , as well as rapidly developing single-particle three-dimensional (3D) reconstruction techniques of cryo electron microscopy (cryo-EM) images that provide high-resolution structural characterization of biological complexes 11-13. In contrast, such single-particle 3D
ISSN:0028-0836
1476-4687
DOI:10.1038/s41586-018-0221-0