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Functionalization of developed bacterial cellulose with magnetite nanoparticles for nanobiotechnology and nanomedicine applications

[Display omitted] •Magnetic material from bacterial cellulose with Fe3O4NPs were synthesis.•Fe3O4NP-INS-(DABC-EDA-Bzl) shows stronger antimicrobial and cytotoxic activities.•Fe3O4NP-INS-(DABC-EDA-Bzl) has non-cytotoxicitiy towards normal cells.•Fe3O4NP-INS-(DABC-EDA-Bzl) shows extraordinary platform...

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Published in:Carbohydrate polymers 2020-11, Vol.247, p.116707, Article 116707
Main Authors: Chaabane, Laroussi, Chahdoura, Hassiba, Mehdaoui, Rahma, Snoussi, Mejdi, Beyou, Emmanuel, Lahcini, Mohammed, V Baouab, Mohamed Hassen
Format: Article
Language:English
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Summary:[Display omitted] •Magnetic material from bacterial cellulose with Fe3O4NPs were synthesis.•Fe3O4NP-INS-(DABC-EDA-Bzl) shows stronger antimicrobial and cytotoxic activities.•Fe3O4NP-INS-(DABC-EDA-Bzl) has non-cytotoxicitiy towards normal cells.•Fe3O4NP-INS-(DABC-EDA-Bzl) shows extraordinary platform in cancer chemotherapy. This paper deals with the preparation of novel magnetic materials made from tetraaza macrocyclic Schiff base bacterial cellulose ligands with magnetite nanoparticles (Fe3O4NPs) through a multi-step procedure for antimicrobial and cytotoxic activities and chemotherapy in cancer treatment. First, the 2,3-dialdehyde bacterial cellulose (DABC) was chemically modified by ethylenediamine (EDA) and benzil (Bzl) in the presence of ferrous ions. Then, the magnetite nanoparticles (Fe3O4NPs) was produced inside the complex [Fe(DABC-EDA-Bzl)Cl2] through a co-precipitation method. In nanobiotechnology, the magnetic [Fe3O4NP-INS-(DABC-EDA-Bzl)] material was showed moderate antimicrobial and cytotoxic activities against different species and cells, respectively. In particular, the magnetic [Fe3O4NP-INS-(DABC-EDA-Bzl)] material have not any cytotoxic activity towards peripheral blood mononucleocyte (PBMC) cells. Anti-tumor studies demonstrated that the magnetic [Fe3O4NP-INS-(DABC-EDA-Bzl)] material effectively inhibits the growth of the CT26 tumor model in BALB/c mice compared with other resulting materials throughout the experimental period and can be effective drug delivery in nanomedicine.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2020.116707